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Open AccessFighting malaria in Madhya Pradesh (Central India): Are we loosing the battle?
Malaria control in Madhya Pradesh is complex because of vast tracts of forest with tribal settlement. Fifty four million individuals of various ethnic origins, accounting for 8% of the total population of Indi...
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Open AccessMacrophage migration inhibitory factor is associated with mortality in cerebral malaria patients in India
Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine implicated in the pathogenesis of a number of human diseases including inflammatory neurological diseases. Its role in the pathogenesi...
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Open AccessAnti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin
Herbal extracts of Andrographis paniculata (AP) and Hedyotis corymbosa (HC) are known as hepato-protective and fever-reducing drugs since ancient time and they have been used regularly by the people in the south ...
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Open AccessGenome-wide SNP genoty** highlights the role of natural selection in Plasmodium falciparumpopulation divergence
The malaria parasite Plasmodium falciparum exhibits abundant genetic diversity, and this diversity is key to its success as a pathogen. Previous efforts to study genetic diversity in P. falciparum have begun to e...
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Open AccessThe usefulness of a new rapid diagnostic test, the First Response® Malaria Combo (pLDH/HRP2) card test, for malaria diagnosis in the forested belt of central India
Malaria presents a diagnostic challenge in tribal belt of central India where two Plasmodium species, Plasmodium falciparum and Plasmodium vivax, are prevalent. In these areas, rapid detection of the malaria para...
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Open AccessAntibody responses to the merozoite surface protein-1 complex in cerebral malaria patients in India
Plasmodium falciparum infection causes cerebral malaria (CM) in a subset of patients with anti-malarial treatment protecting only about 70% to 80% of patients. Why a subset of malaria patients develops CM complic...
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Open AccessDetermination of nitric oxide metabolites, nitrate and nitrite, in Anopheles culicifacies mosquito midgut and haemolymph by anion exchange high-performance liquid chromatography: plausible mechanism of refractoriness
The diverse physiological and pathological role of nitric oxide in innate immune defenses against many intra and extracellular pathogens, have led to the development of various methods for determining nitric o...
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Open AccessPolymorphisms of TNF-enhancer and gene for FcγRIIa correlate with the severity of falciparum malaria in the ethnically diverse Indian population
Susceptibility/resistance to Plasmodium falciparum malaria has been correlated with polymorphisms in more than 30 human genes with most association analyses having been carried out on patients from Africa and sou...
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Open AccessSequence diversity and natural selection at domain I of the apical membrane antigen 1 among Indian Plasmodium falciparum populations
The Plasmodium falciparum apical membrane antigen 1 (AMA1) is a leading malaria vaccine candidate antigen. The complete AMA1 protein is comprised of three domains where domain I exhibits high sequence polymorphis...
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Open AccessGenetic structure of Plasmodium falciparum field isolates in eastern and north-eastern India
Molecular techniques have facilitated the studies on genetic diversity of Plasmodium species particularly from field isolates collected directly from patients. The msp-1 and msp-2 are highly polymorphic markers a...
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Open AccessCongenital malaria with atypical presentation: A case report from low transmission area in India
Malaria during first few months of life may be due to transplacental transfer of parasitized maternal erythrocytes. Although IgG and IgM antimalarial antibodies can be detected in maternal blood, only IgG anti...
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Open AccessA community-based health education programme for bio-environmental control of malaria through folk theatre (Kalajatha) in rural India
Health education is an important component in disease control programme. Kalajatha is a popular, traditional art form of folk theatre depicting various life processes of a local socio-cultural setting. It is an e...
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Open AccessAllelic dimorphism of Plasmodium vivax gam-1 in the Indian subcontinent
Genetic polymorphism is an inevitable component of a complex organism especially in multistage infectious organisms such as malaria parasites. Understanding the population genetic structure of the parasites wo...
