152 Result(s)
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Life Sciences
Animal Genetics and Genomics
Evolutionary Biology
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Article
Open AccessMulti-omics analysis dissects the genetic architecture of seed coat content in Brassica napus
Brassica napus is an important vegetable oil source worldwide. Seed coat content is a complex quantitative trait that negatively correlates with the seed oil content in B. napus.
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Open AccessGenome-wide analysis and functional annotation of chromatin-enriched noncoding RNAs in rice during somatic cell regeneration
Plants have the remarkable ability to generate callus, a pluripotent cell mass that acquires competence for subsequent tissue regeneration. Global chromatin remodeling is required for this cell fate transition...
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Open AccessThe genome of oil-Camellia and population genomics analysis provide insights into seed oil domestication
As a perennial crop, oil-Camellia possesses a long domestication history and produces high-quality seed oil that is beneficial to human health. Camellia oleifera Abel. is a sister species to the tea plant, which ...
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Open AccessLandscape of transcription termination in Arabidopsis revealed by single-molecule nascent RNA sequencing
The dynamic process of transcription termination produces transient RNA intermediates that are difficult to distinguish from each other via short-read sequencing methods.
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Open AccessA systems genetics approach reveals PbrNSC as a regulator of lignin and cellulose biosynthesis in stone cells of pear fruit
Stone cells in fruits of pear (Pyrus pyrifolia) negatively influence fruit quality because their lignified cell walls impart a coarse and granular texture to the fruit flesh.
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Open AccessTranscription-coupled structural dynamics of topologically associating domains regulate replication origin efficiency
Metazoan cells only utilize a small subset of the potential DNA replication origins to duplicate the whole genome in each cell cycle. Origin choice is linked to cell growth, differentiation, and replication st...
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Open AccessPrime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression
Most single nucleotide variants (SNVs) occur in noncoding sequence where millions of transcription factor binding sites (TFBS) reside. Here, a comparative analysis of CRISPR-mediated homology-directed repair (...
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Open AccessGiotto: a toolbox for integrative analysis and visualization of spatial expression data
Spatial transcriptomic and proteomic technologies have provided new opportunities to investigate cells in their native microenvironment. Here we present Giotto, a comprehensive and open-source toolbox for spat...
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A conservation-oriented SNP panel for Smallmouth Bass (Micropterus dolomieu), with emphasis on Interior Highlands lineages
The Smallmouth Bass (Micropterus dolomieu; SMB) is a widely distributed black bass species, but the southwestern edge of the species range within the Interior Highlands contains some of the most divergent ecotype...
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Article
Cloning and expression of AGL19 gene in two Lonicera macranthoides varieties
AGLl9 is an important regulator for flowering in plants and critical in controlling the morphogenesis of flower organs. The full-length cDNAs of AGL19 in conventional Lonicera macranthoides (Lm-AGL19) and the mut...
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Open AccessFlsnRNA-seq: protoplasting-free full-length single-nucleus RNA profiling in plants
The broad application of single-cell RNA profiling in plants has been hindered by the prerequisite of protoplasting that requires digesting the cell walls from different types of plant tissues. Here, we presen...
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Article
Identification of hybrid green peafowl using mitochondrial and nuclear markers
Green peafowl (Pavo muticus), a representative of the Southeast Asia Phasianidae, is assessed as globally endangered with populations that are declining. It is highly sensitive to human disturbance and habitat ch...
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Open AccessClonal tracing reveals diverse patterns of response to immune checkpoint blockade
Immune checkpoint blockade (ICB) therapy has improved patient survival in a variety of cancers, but only a minority of cancer patients respond. Multiple studies have sought to identify general biomarkers of IC...
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Open AccessGenome-wide analysis of expression QTL (eQTL) and allele-specific expression (ASE) in pig muscle identifies candidate genes for meat quality traits
Genetic analysis of gene expression level is a promising approach for characterizing candidate genes that are involved in complex economic traits such as meat quality. In the present study, we conducted expres...
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Open AccessAn integrated peach genome structural variation map uncovers genes associated with fruit traits
Genome structural variations (SVs) have been associated with key traits in a wide range of agronomically important species; however, SV profiles of peach and their functional impacts remain largely unexplored.
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Correction to: Complex patterns of genetic and morphological differentiation in the Smallmouth Bass subspecies (Micropterus dolomieu dolomieu and M. d. velox) of the Central Interior Highlands
In the original publication of the article, Table 2 was published incorrectly. The correct Table 2 is given in this Correction.
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Complex patterns of genetic and morphological differentiation in the Smallmouth Bass subspecies (Micropterus dolomieu dolomieu and M. d. velox) of the Central Interior Highlands
Due to geologic processes and recent anthropogenic introductions, patterns of genetic and morphological diversity within the Smallmouth Bass (Micropterus dolomieu), which are endemic to the central and eastern Un...
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Open AccesssgBE: a structure-guided design of sgRNA architecture specifies base editing window and enables simultaneous conversion of cytosine and adenosine
We present a base editing system, in which base editors are attached to different sites of sgRNA scaffold (sgBE). Each independent sgBE has its own specific editing pattern for a given target site. Among teste...
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Open AccessIntegrative analyses of single-cell transcriptome and regulome using MAESTRO
We present Model-based AnalysEs of Transcriptome and RegulOme (MAESTRO), a comprehensive open-source computational workflow (http://github.com/liulab-dfci/MAESTRO)...
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Arm-Swinging in the Red-Shanked Douc (Pygathrix nemaeus): Implications of Body Mass
Across the primates, larger body mass often necessitates below-branch locomotion (such as arm-swinging or brachiation). While colobines are typically considered arboreal quadrupeds, Pygathrix exhibits a high degr...
