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Open AccessMesenchymal stem cell therapy induces FLT3L and CD1c+ dendritic cells in systemic lupus erythematosus patients
Allogeneic mesenchymal stem cells (MSCs) exhibit immunoregulatory function in human autoimmune diseases such as systemic lupus erythematosus (SLE), but the underlying mechanisms remain incompletely understood....
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Article
Open AccessCharacteristics of Atmospheric Reactive Nitrogen Deposition in Nyingchi City
Atmospheric reactive nitrogen (N) deposition has been proven to be an important nutrient input from external environments to forest ecosystems. However, the magnitude of atmospheric N deposition in the Tibetan...
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Open AccessA vegetation configuration pattern with a high-efficiency purification ability for TN, TP, AN, AP, and COD based on comprehensive assessment results
To identify a vegetation configuration pattern with a high-efficiency purification ability for total nitrogen (TN), available nitrogen (AN), total phosphorous (TP), available phosphorous (AP), and chemical oxy...
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Open AccessGenetic effects of BDKRB2 and KNG1 on deep venous thrombosis after orthopedic surgery and the potential mediator
Deep venous thrombosis (DVT) is a common complication of orthopedic surgery. Genetic risk factors and high heritability carried a substantial risk of DVT. In this study, we aimed to investigate the potential a...
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Article
Open AccessThe discovered chimeric protein plays the cohesive role to maintain scallop byssal root structural integrity
Adhesion is essential for many marine sessile organisms. Unraveling the compositions and assembly of marine bioadheisves is the fundamental to understand their physiological roles. Despite the remarkable diver...
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Open AccessAssociation between H-type Hypertension and Asymptomatic Extracranial Artery Stenosis
Asymptomatic extracranial artery stenosis (ECAS) is a well-known risk factor for stroke and H-type hypertension, which is defined as hypertension with hyperhomocysteinemia, is associated with cardio-cerebrovas...
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Open AccessComprehensive in situ co-detection of aneuploid circulating endothelial and tumor cells
Conventional circulating tumor cell (CTC) detection strategies rely on cell surface marker EpCAM and intracellular cytokeratins (CKs) for isolation and identification, respectively. Application of such methods...
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Article
Open AccessDanhong injection reduces vascular remodeling and up-regulates the Kallikrein-kinin system in spontaneously hypertensive rats
Although Danhong injection (DHI) is one of the most prescribed cardiovascular medicines in China, its therapeutic indications and mechanisms remain partially defined. We now identify molecular targets of DHI i...
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Open AccessDifference in Cerebral Circulation Time between Subtypes of Moyamoya Disease and Moyamoya Syndrome
In this study, we evaluated the differences in hemodynamics between hemorrhagic and non-hemorrhagic moyamoya disease (MMD) and moyamoya syndrome (MMS) by measuring cerebral circulation time (CCT). This case-co...
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Open AccessAssociation between High-density-lipoprotein-cholesterol Levels and the Prevalence of Asymptomatic Intracranial Arterial Stenosis
Intracranial atherosclerotic stenosis (ICAS) is a common cause of ischemic stroke, and a low level of high-density lipoprotein cholesterol (HDL-C) is also considered to be a predictor for stroke. However, the ...
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Article
Open AccessAll-into-one strategy to synthesize mesoporous hybrid silicate microspheres from naturally rich red palygorskite clay as high-efficient adsorbents
A mesoporous hybrid silicate microsphere with superior adsorption performance has been successfully synthesized by employing an “all-into-one” strategy and a simple one-pot hydrothermal process using naturally...
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Open AccessAsymptomatic Extracranial Artery Stenosis and the Risk of Cardiovascular and Cerebrovascular Diseases
Asymptomatic extracranial artery stenosis (ECAS) is a well-known risk factor for stroke events, but it remains unclear whether it has the same role in predicting cardiovascular and cerebrovascular diseases, es...
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Open AccessAbrogation of CC chemokine receptor 9 ameliorates ventricular remodeling in mice after myocardial infarction
CC chemokine receptor 9 (CCR9), which is a unique receptor for CC chemokine ligand (CCL25), is mainly expressed on lymphocytes, dendritic cells (DCs) and monocytes/macrophages. CCR9 mediates the chemotaxis of ...
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Article
Open AccessThe co-chaperone Cdc37 regulates the rabies virus phosphoprotein stability by targeting to Hsp90AA1 machinery
Cdc37, as a kinase-specific co-chaperone of the chaperone Hsp90AA1 (Hsp90), actively aids with the maturation, stabilization and activation of the cellular or viral kinase/kinase-like targets. Phosphoprotein (...
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Open AccessAnalysis of proteome dynamics inside the silk gland lumen of Bombyx mori
The silk gland is the only organ where silk proteins are synthesized and secreted in the silkworm, Bombyx mori. Silk proteins are stored in the lumen of the silk gland for around eight days during the fifth insta...
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Open AccessExcess salt exacerbates blood-brain barrier disruption via a p38/MAPK/SGK1-dependent pathway in permanent cerebral ischemia
High salt diet (HSD) is one of the most important risk factors that contribute to many vascular diseases including ischemic stroke. One proposed mechanism underlying the disruption of blood-brain barrier (BBB)...
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Open AccessEffect of Menopausal Status on Carotid Intima-Media Thickness and Presence of Carotid Plaque in Chinese Women Generation Population
Menopause is an important physiological stage in women's life. The potential association of menopause with carotid intima-media thickness as well as with occurrence and stability of carotid plaque in Chinese f...
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Open AccessSurrounding Sensitive Electronic Properties of Bi2Te3 Nanoplates—Potential Sensing Applications of Topological Insulators
Significant efforts have been paid to exploring the fundamental properties of topological insulators (TIs) in recent years. However, the investigation of TIs as functional materials for practical device applic...
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Open AccessThe locust genome provides insight into swarm formation and long-distance flight
Locusts are one of the world’s most destructive agricultural pests and represent a useful model system in entomology. Here we present a draft 6.5 Gb genome sequence of Locusta migratoria, which is the largest ani...
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Bypass of a protein barrier by a replicative DNA helicase
Replicative DNA helicases generally unwind DNA as a single hexamer that encircles and translocates along one strand of the duplex while excluding the complementary strand (known as steric exclusion). By contra...