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Article
Nucleic acid aptamer-based electrochemical sensor for the detection of serum P-tau231 and the instant screening test of Alzheimer’s disease
The instant screening of patients with a tendency towards develo** Alzheimer’s disease (AD) is significant for providing preventive measures and treatment. However, the current imaging-based technology canno...
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Article
Open AccessImpaired cerebral microvascular endothelial cells integrity due to elevated dopamine in myasthenic model
Myasthenia gravis is an autoimmune disease characterized by pathogenic antibodies that target structures of the neuromuscular junction. However, some patients also experience autonomic dysfunction, anxiety, de...
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Article
Open AccessThe ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity
Identification of positive regulators of T-cell immunity induced during autoimmune diseases is critical for develo** novel therapies. The endoplasmic reticulum resident ubiquitin ligase Hrd1 has recently eme...
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Article
Open AccessExcess salt exacerbates blood-brain barrier disruption via a p38/MAPK/SGK1-dependent pathway in permanent cerebral ischemia
High salt diet (HSD) is one of the most important risk factors that contribute to many vascular diseases including ischemic stroke. One proposed mechanism underlying the disruption of blood-brain barrier (BBB)...
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Article
Open AccessUbiquitin-specific protease 22 is a deubiquitinase of CCNB1
The elevated level of CCNB1 indicates more aggressive cancer and poor prognosis. However, the factors that cause CCNB1 upregulation remain enigmatic. Herein, we identify USP22 as a CCNB1 interactor and discove...
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Article
Bone Marrow Stromal Cells Inhibit the Activation of Liver Cirrhotic Fat-Storing Cells via Adrenomedullin Secretion
Cirrhosis, or liver fibrosis, which is mainly triggered by cirrhosis fat-storing cells (CFSCs) activation, has traditionally been considered an irreversible disease. However, recent observations indicate that ...
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Article
Open AccessAccumulation of natural killer cells in ischemic brain tissues and the chemotactic effect of IP-10
Stroke is accompanied by a distinguished inflammatory reaction that is initiated by the infiltration of immunocytes, expression of cytokines, and other inflammatory mediators. As natural killer cells (NK cells...
