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Article
Modeling and Evaluation of the Joint Prevention and Control Mechanism for Curbing COVID-19 in Wuhan
The spread of COVID-19 in Wuhan was successfully curbed under the strategy of “Joint Prevention and Control Mechanism.” To understand how this measure stopped the epidemics in Wuhan, we establish a compartment...
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Chapter and Conference Paper
A Perceptron Mixture Model of Intrusion Detection for Safeguarding Electronic Health Record System
Electronic Health Record System, EHRS, has recently become a common healthcare information technology that has been widely adopted by many physicians. Due to compromised internal structures and systems, safegu...
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Article
Open AccessPaediatric oncology ward nurses’ experiences of patients’ deaths in China: A qualitative study
Considering cancer death is second only to accidental death in the number of lives claimed each year,nurses in paediatric oncology wards often experience helplessness, sadness, frustration and such other adver...
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Article
Multi-modality measurement and comprehensive analysis of hepatocellular carcinoma using synchrotron-based microscopy and spectroscopy
The visualization and data mining of tumor multidimensional information may play a major role in the analysis of the growth, metastasis, and microenvironmental changes of tumors while challenging traditional i...
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Article
Open Accessrno-miR-128-3p promotes apoptosis in rat granulosa cells (GCs) induced by norepinephrine through Wilms tumor 1 (WT1)
The mechanism related to ovarian follicular is complex, which has not been fully elucidated. Abundant reports have confirmed that the ovarian function development is closely related to sympathetic innervation....
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Article
Evolutionary synthetic oversampling technique and cocktail ensemble model for warfarin dose prediction with imbalanced data
To improve the accuracy of warfarin daily dose prediction, we develop an evolutionary synthetic oversampling technique (ESMOTE) with a cocktail ensemble model (CEM) called ESMOTE-CEM. Different from convention...
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Article
Open AccessAssociation of thrombocytopenia and infection in patients with ST-elevation myocardial infarction undergoing percutaneous coronary intervention
The impact of thrombocytopenia on infection in patients with ST-elevation myocardial infarction (STEMI) remains poorly understood.
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Article
Optimal Control of Mitigation Strategies for Dengue Virus Transmission
Dengue virus is transmitted by Aedes mosquitoes, posing threat to people’s health and leading to great economic cost in many tropical and subtropical regions. We develop an ordinary differential equation model ta...
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Article
An optically active isochroman-2H-chromene conjugate potently suppresses neuronal oxidative injuries associated with the PI3K/Akt and MAPK signaling pathways
Increasing evidence suggests that the use of potent neuroprotective agents featured with novel pharmacological mechanism would offer a promising strategy to delay or prevent the progression of neurodegeneratio...
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Article
Advanced Magnetic Resonance Studies of Tetraphenylporphyrinatoiron(III) Halides
High-Frequency and -Field EPR (HFEPR) studies of Fe(TPP)X (X = F, Cl, Br; I, TPP2−= meso-tetraphenylporphyrinate dianion) and far-IR magnetic spectroscopic (FIRMS) studies of Fe(TPP)Br and Fe(TPP)I have been cond...
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Article
Methodology development and application of X-ray imaging beamline at SSRF
This paper introduces some latest developments regarding the X-ray imaging methodology and applications of the X-ray imaging and biomedical application beamline (BL13W1) at Shanghai Synchrotron Radiation Facil...
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Article
Phase I, First-in-Human, Single and Multiple Ascending Dose- and Food-Effect Studies to Assess the Safety, Tolerability and Pharmacokinetics of a Novel Anti-hepatitis B Virus Drug, Bentysrepinine (Y101), in Healthy Chinese Subjects
Bentysrepinine (Y101), a derivative of repensine (a compound isolated from Dichondra repens Forst), is a novel phenylalanine dipeptide currently under development for the treatment of hepatitis B virus (HBV). ...
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Article
Open AccessImmunization with a fusion protein vaccine candidate generated from truncated peptides of human enterovirus 71 protects mice from lethal enterovirus 71 infections
Prophylactic vaccines are critical in preventing hand, foot, and mouth disease (HFMD) primarily caused by human enterovirus 71 (EV71) infection. Children aged less than 5 years are especially susceptible to EV...
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Article
Coadministration of vindesine with high-dose methotrexate therapy increases acute kidney injury via BCRP, MRP2, and OAT1/OAT3
To investigate whether coadministration of vindesine is a risk factor for acute kidney injury caused by high-dose methotrexate in patients with hematologic malignancies and identify its mechanism.
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Article
Multicenter-Based Population Pharmacokinetic Analysis of Ciclosporin in Hematopoietic Stem Cell Transplantation Patients
To explore the contribution of physiological characteristics to variability in ciclosporin pharmacokinetics in hematopoietic stem cell transplantation patients.
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Article
Relationship between warfarin dosage and international normalized ratio: a dose–response analysis and evaluation based on multicenter data
The objectives of the study were to establish a dose–response model for warfarin based on the relationship between daily warfarin dose and international normalized ratio (INR) and to evaluate the stability and...
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Article
Discrete-time quantum walk search on Johnson graphs
The Johnson graph J (n, k) is defined by n symbols, where vertices are k-element subsets of the symbols, and vertices are adjacent if they differ in exactly one symbol. In particular, both J (n, 1), the complete ...
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Article
Chimeric Newcastle disease virus-vectored vaccine protects chickens against H9N2 avian influenza virus in the presence of pre-existing NDV immunity
A chimeric Newcastle disease virus (NDV) vector (NDV/AI4-TFHN) was constructed with the replacement of the ectodomains of the fusion and hemagglutinin-neuraminidase proteins by those from avian paramyxovirus t...
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Article
Population pharmacokinetics of theophylline in adult Chinese patients with asthma and chronic obstructive pulmonary disease
Background Theophylline has a narrow therapeutic range and large interindividual variability in blood levels, so a thorough understanding of its pharmacokinetic characteristics is essential. Population pharmacoki...
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Article
Open AccessSpin–phonon couplings in transition metal complexes with slow magnetic relaxation
Spin–phonon coupling plays an important role in single-molecule magnets and molecular qubits. However, there have been few detailed studies of its nature. Here, we show for the first time distinct couplings of g ...
