147 Result(s)

Article

Clinical prognosis and related molecular features of hepatitis B-associated adolescent and young adult hepatocellular carcinoma

Inattention has been given to the pathogenesis of adolescent and young adult (AYA) hepatocellular carcinoma (HCC). Due to the more advanced tumor progression and poorer prognosis of AYA-HCC, together with a be...

Tao Lv, Bo Zhang, ** Xu, Chenhao Jiang, Daofeng Zheng, Diao He… in Human Genomics (2023)

Article

The potential of high-order features of routine blood test in predicting the prognosis of non-small cell lung cancer

Numerous studies have demonstrated that the high-order features (HOFs) of blood test data can be used to predict the prognosis of patients with different types of cancer. Although the majority of blood HOFs ca...

Li** Luo, Yubo Tan, Shixuan Zhao, Man Yang, Yurou Che, Kezhen Li, Jieke Liu… in BMC Cancer (2023)

Article

Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis

Chemoresistance is the main reason for the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). Thus, there is an urgent need to screen out new targets and compounds to reverse chemotherapeutic resistance.

Tianxing Zhou, Yongjie **e, Xupeng Hou… in Journal of Experimental & Clinical Cancer … (2023)

Article

Retraction Note: Characterization of Preclinical Pharmacokinetic Properties and Prediction of Human PK Using a Physiologically Based Pharmacokinetic Model for a Novel Anti-Arrhythmic Agent Sulcardine Sulfate

Chang Ren, Yao Wang, Mei Zhang, Dexuan Kong, Chen Ning… in Pharmaceutical Research (2023)

Article

Identification of hub genes and potential molecular mechanisms related to radiotherapy sensitivity in rectal cancer based on multiple datasets

Radiotherapy resistance is the main cause of low tumor regression for locally advanced rectum adenocarcinoma (READ). The biomarkers correlated to radiotherapy sensitivity and potential molecular mechanisms hav...

Pengfei Zhao, Hongchao Zhen, Hong Zhao, Yongjie Huang… in Journal of Translational Medicine (2023)

Article

Integrative analysis of bulk and single-cell gene expression profiles to identify tumor-associated macrophage-derived CCL18 as a therapeutic target of esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is a common gastrointestinal malignancy with poor patient prognosis. Current treatment for ESCC, including immunotherapy, is only beneficial for a small subset of pati...

**nghua Sui, Chunxia Chen, **uman Zhou… in Journal of Experimental & Clinical Cancer … (2023)

Article

Identification of MET fusions as novel therapeutic targets sensitive to MET inhibitors in lung cancer

Alterations in the MET gene, including amplifications and exon 14 skip** mutations, have been identified as actionable oncogenic alterations. However, MET fusions are rarely detected in lung cancer, and thei...

Dantong Sun, Weizheng Wu, Li Wang, Jialin Qu… in Journal of Translational Medicine (2023)

Article

Water channel protein AQP1 in cytoplasm is a critical factor in breast cancer local invasion

Metastasis of breast cancer grows from the local invasion to the distant colonization. Blocking the local invasion step would be promising for breast cancer treatment. Our present study demonstrated AQP1 was a...

Zhifang Guo, Huikun Zhang, **aoli Liu… in Journal of Experimental & Clinical Cancer … (2023)

Article

The reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged sword

In Parkinson's disease (PD), neurotoxic microglia, Th1 cells, and Th17 cells are overactivated. Overactivation of these immune cells exacerbates the disease process and leads to the pathological development of...

Yuxiang Xu, Yongjie Li, Changqing Wang, Tingting Han… in Journal of Neuroinflammation (2023)

Article

Associations of types of grains and lifestyle with all-cause mortality among Chinese adults aged 65 years or older: a prospective cohort study

Little is known on the association of types of grains with mortality and the moderating effect of lifestyle on this association. This study aims to evaluate the single or joint associations of types of grains ...

Yongjie Chen, Boran Sun, Caihong Wang, Keming Zhang… in Journal of Translational Medicine (2023)

Article

A systematic review and meta-analysis of inflammatory biomarkers in Parkinson’s disease

Neuroinflammation plays a crucial role in the pathogenesis of Parkinson’s disease (PD), but controversies persist. Studies reporting concentrations of blood or cerebrospinal fluid (CSF) markers for patients wi...

Yi Qu, Jiangting Li, Qixiong Qin, Danlei Wang, **gwei Zhao… in npj Parkinson's Disease (2023)

Article

Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study

Diet and chronic inflammation might play a major role in the pathogenesis of mild cognitive impairment (MCI). In addition, peripheral blood leukocyte telomere length (LTL) and mitochondrial DNA copy number (mt...

Qian Liu, Zhenshu Li, Ling Huang, Dezheng Zhou, **gzhu Fu… in Immunity & Ageing (2023)