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Article
Open AccessType III secretion system effector YfiD inhibits the activation of host poly(ADP-ribose) polymerase-1 to promote bacterial infection
Modulation of cell death is a powerful strategy employed by pathogenic bacteria to evade host immune clearance and occupy profitable replication niches during infection. Intracellular pathogens employ the type...
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Chapter and Conference Paper
Enhancing Daily Life Through an Interactive Desktop Robotics System
In this demo, we develop an intelligent desktop operating robot designed to assist humans in their daily lives by comprehending natural language with large language models and performing a variety of desktop-r...
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Article
Effects of different light qualities and plant growth regulators on the growth and secondary metabolite content of Lonicera macranthoides seedlings
Lonicera macranthoides, a medicinal herb mainly distributed in southern China, is widely utilized in traditional Chinese medicine for its high yield and strong pharmacological properties rich in phenolic acids an...
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Article
Discrepancy of synaptic and microtubular protein phosphorylation in the hippocampus of APP/PS1 and MAPT×P301S transgenic mice at the early stage of Alzheimer’s disease
Alzheimer’s disease (AD) is the most common neurodegenerative disorder, and is caused by multiple pathological factors, such as the overproduction of β-amyloid (Aβ) and the hyperphosphor...
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Article
Identification of determinants for entering into a viable but nonculturable state in Vibrio alginolyticus by Tn-seq
The viable but nonculturable (VBNC) state is a dormant state of nonsporulating bacteria that enhances survival in adverse environments. Systematic genome-wide research on the genetic basis of VBNC formation is...
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Article
Open AccessShear behavior of sliding zone soil of loess landslides via ring shear tests in the South **gyang Plateau
Since the 1970s, a large number of loess collapses and landslides have occurred in the Loess Plateau of China due to water diversion and irrigation projects. A large amount of ancient landslide deposits are ac...
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Article
Coordinate regulation of carbohydrate metabolism and virulence by PtsH in pathogen Edwardsiella piscicida
Carbohydrate metabolism of bacterial pathogens conducts crucial roles in regulating pathogenesis but the molecular mechanisms by which metabolisms and virulence are been modulated and coordinated remain to be ...
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Article
Open AccessS-nitrosylation-mediated activation of a histidine kinase represses the type 3 secretion system and promotes virulence of an enteric pathogen
Vibrio parahaemolyticus is the leading cause of seafood-borne diarrheal diseases. Experimental overproduction of a type 3 secretion system (T3SS1) in this pathogen leads to decreased intestinal colonization, whic...
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Article
Genetic analysis of type 2 tri-allelic pattern at TPOX locus in the Chinese Han population
Tri-allelic patterns can occasionally be observed during the profiling of short tandem repeats (STRs) in routine forensic practice. In previous studies, the Type 2 tri-allelic pattern at TPOX has been widely s...
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Article
Identification and study of InV as an inverse autotransporter family representative in Edwardsiella piscicida
Invasins and intimins, members of virulence-related adhesin family which is involved in attachment and adherence to epithelial cells during infection, are found in various pathogens. These pathogens can attach...
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Article
Open AccessA unique DNA-binding mode of African swine fever virus AP endonuclease
African swine fever virus (ASFV) is highly contagious and can cause lethal disease in pigs. ASFV is primarily replicated in the cytoplasm of pig macrophages, which is oxidative and caused constant damage to AS...
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Article
The mechanisms of a loess landslide triggered by diversion-based irrigation: a case study of the South **gyang Platform, China
Continuous use of diversion-based irrigation has been associated with an increase in the frequency of loess landslides on the South **gyang Platform, Shaanxi, China. A loess landslide event with a maximum sli...
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Article
Open AccessEnhanced lincomycin A production by calcium gluconate feeding in fermentation of Streptomyces lincolnensis
Lincomycin A is a clinically important antibiotic produced by Streptomyces lincolnensis that is used against gram-positive bacteria. To increase the yield of lincomycin A, a calcium gluconate feeding strategy was...
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Article
Open AccessCRISPR–Cas9-mediated genomic multiloci integration in Pichia pastoris
Pichia pastoris (syn. Komagataella phaffii) is a widely used generally recognized as safe host for heterologous expression of proteins in both industry and academia. Recently, it has been shown to be a potentiall...
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Article
Open AccessSensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish
The noncanonical inflammasome is critical for cytosolic sensing of Gram-negative pathogens. Here, we show that bacterial infection induces caspy2 activation in zebrafish fibroblasts, which mediates pyroptosis ...
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Article
An effective established biosensor of bifunctional probes-labeled AuNPs combined with LAMP for detection of fish pathogen Streptococcus iniae
In purpose of valid Streptococcus iniae detection, we established a colorimetric biosensor using gold nanoparticles (AuNPs) labeled with dual functional probes and along with loop-mediated isothermal amplificatio...
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Article
Propagation of the Stress Wave Through the Filled Joint with Linear Viscoelastic Deformation Behavior Using Time-Domain Recursive Method
The dynamic behavior of filled joints is mostly controlled by the filled medium. In addition to nonlinear elastic behavior, viscoelastic behavior of filled joints is also of great significance. Here, a theoret...
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Article
Shear wave velocity imaging of landslide debris deposited on an erodible bed and possible movement mechanism for a loess landslide in **gyang, **’an, China
The South **gyang Plateau, with a total area of 70 km2, is located in Shaanxi Province, China. Since 1976, more than 50 landslides of different types have occurred repeatedly on the edge slopes of the plateau du...
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Article
Open AccessTransposon insertion sequencing reveals T4SS as the major genetic trait for conjugation transfer of multi-drug resistance pEIB202 from Edwardsiella
Conjugation is a major type of horizontal transmission of genes that involves transfer of a plasmid into a recipient using specific conjugation machinery, which results in an extended spectrum of bacterial ant...
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Article
De novo transcriptome sequencing of marine-derived Aspergillus glaucus and comparative analysis of metabolic and developmental variations in response to salt stress
Aspergillus glaucus HB1-19 is a typical marine-derived fungus preferring the dependence on sea water for its growth, asexual development and polyketides biosynthesis. Therein, salt stress...
