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Article
Open AccessBazi Bushen ameliorates age-related energy metabolism dysregulation by targeting the IL-17/TNF inflammatory pathway associated with SASP
Chronic inflammation and metabolic dysfunction are key features of systemic aging, closely associated with the development and progression of age-related metabolic diseases. Bazi Bushen (BZBS), a traditional C...
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Article
Open AccessExperience of chinese counter-marching nurses with COVID-19 patients’ death in Wuhan: a qualitative study
The COVID-19 pandemic was occurring worldwide with over a 6.5 million deaths. It’s important to explore the instructions for the global nursing community by identifying the personal co** methods of Chinese n...
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Article
Open AccessWater channel protein AQP1 in cytoplasm is a critical factor in breast cancer local invasion
Metastasis of breast cancer grows from the local invasion to the distant colonization. Blocking the local invasion step would be promising for breast cancer treatment. Our present study demonstrated AQP1 was a...
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Article
Open AccessThe alternative splicing of intersectin 1 regulated by PTBP1 promotes human glioma progression
Intersectin 1 (ITSN1) contains two isoforms: ITSN1-S and ITSN1-L, which are highly regulated by alternative splicing. Our previous results showed that the two isoforms of ITSN1 displayed opposite functions: IT...
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Article
Open AccessEndocytic protein intersectin1-S shuttles into nucleus to suppress the DNA replication in breast cancer
Breast cancer is the most common type of cancer worldwide. However, the well-known molecular biomarkers are not enough to meet the needs of precision medicine. In search for novel targets in this regard, we re...
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Article
Open AccessAquaporin 1 promotes sensitivity of anthracycline chemotherapy in breast cancer by inhibiting β-catenin degradation to enhance TopoIIα activity
Anthracyclines are a class of conventional and commonly used frontline chemotherapy drugs to treat breast cancer. However, the anthracycline-based regimens can only reduce breast cancer mortality by 20–30%. Fu...
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Article
Open AccessAlternative splicing-derived intersectin1-L and intersectin1-S exert opposite function in glioma progression
Intersectin1 (ITSN1) contains two isoforms: ITSN1-S and ITSN1-L, which is highly regulated by alternative splicing. However, the alteration of alternative splicing and its importance in cancer is still unknown...
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Article
Electron acceleration in the near-Earth magnetotail: test particle calculations in electromagnetic fields from two-dimensional hybrid simulations
Electron acceleration in the near-Earth magnetotail during the substorm period is still an unresolved question. In this paper, by tracing electron trajectories in the dynamically evolving electromagnetic field...
