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Article
Open AccessMicroRNA-218-5p-Ddx41 axis restrains microglia-mediated neuroinflammation through downregulating type I interferon response in a mouse model of Parkinson’s disease
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons in the substantia nigra (SN). Microglia-mediated neuroinflammation has been largely considered on...
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Article
Open AccessA systematic review and meta-analysis of inflammatory biomarkers in Parkinson’s disease
Neuroinflammation plays a crucial role in the pathogenesis of Parkinson’s disease (PD), but controversies persist. Studies reporting concentrations of blood or cerebrospinal fluid (CSF) markers for patients wi...
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Article
Open AccessFreezing of gait is a risk factor for cognitive decline in Parkinson’s disease
Freezing of gait (FOG) and cognitive impairment are serious symptoms of Parkinson’s disease (PD). Understanding the association between FOG and cognition may help formulate specific interventions for PD indivi...
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Chapter and Conference Paper
Dynamic Multi-objective Prediction Strategy for Transfer Learning Based on Imbalanced Data Classification
Prediction strategies based on transfer learning have been proved to be effective in solving Dynamic Multi-Objective Optimization Problems (DMOPs). However, slow running speed impedes the development of this m...
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Article
Open AccessThe effect of alkyl substitution on the oxidative metabolism and mutagenicity of phenanthrene
Alkyl-substituted PAHs may be present in certain petroleum-derived products and in the environment and may eventually end up in consumer products, such as foodstuffs, cosmetics and pharmaceuticals. Safety conc...
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Article
Open AccessPredicting the in vivo developmental toxicity of benzo[a]pyrene (BaP) in rats by an in vitro–in silico approach
Developmental toxicity testing is an animal-intensive endpoints in toxicity testing and calls for animal-free alternatives. Previous studies showed the applicability of an in vitro–in silico approach for predi...
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Article
Effect of dynamic strain aging and precipitation on the hot deformation behavior of 253MA heat-resistant alloy
In this research, we performed an experimental investigation into the influence of dynamic strain aging (DSA) and precipitation behavior on the plastic deformation and microstructure evolution in alloy 253MA c...
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Article
Ammonium pyrrolidinedithiocarbamate-modified activated carbon micro-column extraction for the determination of As(III) in water by graphite furnace atomic absorption spectrometry
A simple and selective method using ammonium pyrrolidinedithiocarbamate modified activated carbon (APDC-AC) as solid phase extractant has been developed for speciation of As(III) in water samples. At pH 1.8–3....
