102 Result(s)
within
Cancer Research
Cell Biology
**na Hong
Article
Life Sciences
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Article
APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function
Adiponectin, also known as Acrp30, is an adipose tissue-derived hormone with anti-atherogenic, anti-diabetic and insulin sensitizing properties1,2,3. Two seven-transmembrane domain-containing proteins, AdipoR1 an...
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Negative regulation of ERK activity by VRK3-mediated activation of VHR phosphatase
Extracellular signal regulated kinases (ERKs) represent a signalling hub in many physiological responses and have pivotal functions in cell proliferation, differentiation, development and death, as well as in ...
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Article
CUL4–DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation
The CUL4–DDB1–ROC1 ubiquitin E3 ligase regulates cell-cycle progression, replication and DNA damage response1,2,3,4. However, the substrate-specific adaptors of this ligase remain uncharacterized. Here, we show t...
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SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination
The p53 tumour suppressor has a key role in the control of cell growth and differentiation, and in the maintenance of genome integrity1,2. p53 is kept labile under normal conditions, but in response to stresses, ...
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Caspase-11 regulates cell migration by promoting Aip1–Cofilin-mediated actin depolymerization
Coordinated regulation of cell migration, cytokine maturation and apoptosis is critical in inflammatory responses. Caspases, a family of cysteine proteases, are known to regulate cytokine maturation and apopto...
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Loss of Drosophila Myb interrupts the progression of chromosome condensation
Completion of chromosome condensation is required before segregation during the mitotic cell cycle to ensure the transmission of genetic material with high fidelity in a timely fashion. In many eukaryotes this...
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p73 supports cellular growth through c-Jun-dependent AP-1 transactivation
The cause or consequence of overexpression of p73 (refs 1, 2), the structural and functional homologue of the tumour-suppressor gene product p53 (refs 3, 4), in human cancers is poorly understood. Here, we report...
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AK2 activates a novel apoptotic pathway through formation of a complex with FADD and caspase-10
Mitochondrial proteins function as essential regulators in apoptosis. Here, we show that mitochondrial adenylate kinase 2 (AK2) mediates mitochondrial apoptosis through the formation of an AK2–FADD–caspase-10 ...
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Open AccessHuman 14-3-3 gamma protein results in abnormal cell proliferation in the develo** eye of Drosophila melanogaster
14-3-3 proteins are a family of adaptor proteins that participate in a wide variety of cellular processes. Recent evidence indicates that the expression levels of these proteins are elevated in some human tumo...
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A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis
The release of amyloid precursor protein (APP) intracellular domain (AICD) may be triggered by extracellular cues through γ-secretase-dependent cleavage. AICD binds to Fe65, which may have a role in AICD-depen...
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Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B
Netrins, a family of secreted molecules, have critical functions in axon guidance and cell migration during neuronal development1,2. In addition to its role as a chemotropic molecule, netrin-1 also acts as a surv...
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Chfr is linked to tumour metastasis through the downregulation of HDAC1
The ubiquitin ligase Chfr polyubiquitylates the histone deacetylase Hdac1, resulting in its proteolysis and the concomitant upregulation of metastasis suppressors, which may provide a molecular explanation for...
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p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug
The tumour suppressor p53 inhibits cancer cell proliferation and induces apoptosis. A new tumour-suppressive effect of p53 is to induce MDM2-dependent degradation of the tumour invasion factor Slug, resulting ...
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Erratum: p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug
Received 29 October 2008; accepted 19 February 2009; published online 17 May 2009; corrected after print 19 May 2009 In the version of this article initially published, the Myc–Ub label in Figure 3c was incorr...
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OsHAL3 mediates a new pathway in the light-regulated growth of rice
Plants show distinct morphologies in different light conditions through a process called photomorphogenesis. A predominant feature of photomorphogenesis is the reduced growth of seedlings under light condition...
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Open AccessProteomics, pathway array and signaling network-based medicine in cancer
Cancer is a multifaceted disease that results from dysregulated normal cellular signaling networks caused by genetic, genomic and epigenetic alterations at cell or tissue levels. Uncovering the underlying prot...
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Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA
Twenty-two microRNAs are found to be amplified or deleted in hepatocellular carcinoma (HCC). miR-151 is encoded by an intron in the focal adhesion kinase FAK-1 gene, with which it is co-transcribed, and increases...
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PP2A activates brassinosteroid-responsive gene expression and plant growth by dephosphorylating BZR1
Brassinosteroids trigger a receptor kinase-mediated signalling pathway to modulate plant development through the dephosphorylation of the BZR transcription factors, which are normally kept inactive by the kina...
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p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs
The epithelial to mesenchymal transition (EMT) has been recently associated with a stem cell phenotype. In breast cancer cell lines and tumours, p53 directly targets the expression of microRNAs that have been ...
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Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells
Human induced pluripotent stem (iPS) cells are remarkably similar to embryonic stem (ES) cells, but recent reports indicate that there may be important differences between them. We carried out a systematic com...
