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Open AccessGlucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer
Cancer cells depend on nicotinamide adenine dinucleotide phosphate (NADPH) to combat oxidative stress and support reductive biosynthesis. One major NADPH production route is the oxidative pentose phosphate pat...
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Article
Open AccessLeukemia inhibitory factor suppresses hepatic de novo lipogenesis and induces cachexia in mice
Cancer cachexia is a systemic metabolic syndrome characterized by involuntary weight loss, and muscle and adipose tissue wasting. Mechanisms underlying cachexia remain poorly understood. Leukemia inhibitory fa...
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Article
Open AccessInhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors
LKB1 and KRAS are the third most frequent co-mutations detected in non-small cell lung cancer (NSCLC) and cause aggressive tumor growth. Unfortunately, treatment with RAS-RAF-MEK-ERK pathway inhibitors has min...
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Publisher Correction: Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response
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Open AccessSOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer
SOD1 is known as the major cytoplasmic superoxide dismutase and an anticancer target. However, the role of SOD1 in cancer is not fully understood. Herein we describe the generation of an inducible Sod1 knockout i...
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Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response
Macroautophagy (hereafter autophagy) degrades and recycles intracellular components to sustain metabolism and survival during starvation. Host autophagy promotes tumor growth by providing essential tumor nutri...
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Author Correction: Autophagy maintains tumour growth through circulating arginine
In this Letter, ‘released’ should have been ‘regulated’ in the sentence starting: ‘Deletion of Atg5 in the host similarly regulated circulating arginine and suppressed tumorigenesis...’ This has been corrected on...
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Autophagy maintains tumour growth through circulating arginine
Autophagy captures intracellular components and delivers them to lysosomes, where they are degraded and recycled to sustain metabolism and to enable survival during starvation1–5. Acute, whole-body deletion of th...
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Open AccessParkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression
Mutations in E3 ubiquitin ligase Parkin have been linked to familial Parkinson’s disease. Accumulating evidence suggests that Parkin is a tumor suppressor, but the underlying mechanism is poorly understood. He...
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Glucose feeds the TCA cycle via circulating lactate
Metabolic flux analysis in mice reveals that lactate often acts as the primary carbon source for the tricarboxylic acid cycle both in normal tissues and in tumour microenvironments.
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Open Access31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one
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Open AccessStarving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors
Calorie restriction (CR) prevents obesity and exerts anticancer effects in many preclinical models. CR is also increasingly being used in cancer patients as a sensitizing strategy prior to chemotherapy regimen...
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Open AccessQ&A: targeting autophagy in cancer—a new therapeutic?
Macroautophagy (autophagy hereafter) captures and degrades intracellular proteins and organelles in lysosomes as a quality control mechanism and recycles their components to sustain survival in starvation. Cel...
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Open AccessRole of autophagy in K-RAS- and B-RAF-driven lung cancers
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Open AccessLC-MS and GC-MS based metabolomics platform for cancer research
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Open AccessRas-driven cancer cells can scavenge exogenous lipids to support their proliferation
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Deconvoluting the context-dependent role for autophagy in cancer
Autophagy is a cellular self-cannibalization process that captures and digests cellular proteins and organelles in lysosomes.
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Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria
IRGM is a human GTPase that triggers autophagy in response to pathogen infection. On Mycobacteria infection, IRGM binds the mitochondrial cardiolipin to induce mitochondrial fission and a general autophagy res...
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Open AccessA randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899
To test the hypothesis that modulation of Bcl-2 with 13-cis retinoic acid (CRA)/interferon-alpha2b (IFN) with paclitaxel (TAX), or mitoxantrone, estramustine and vinorelbine (MEV) will have clinical activity i...
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Production of membrane proteins for NMR studies using the condensed single protein (cSPP) production system
In the Single Protein Production (SPP) method, all E. coli cellular mRNAs are eliminated by the induction of MazF, an ACA-specific mRNA interferase. When an mRNA for a membrane protein, engineered to have no ACA ...
