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Open AccessAuthor Correction: Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix
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Open AccessCancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix
Elevated production of collagen-rich extracellular matrix is a hallmark of cancer-associated fibroblasts (CAFs) and a central driver of cancer aggressiveness. Here we find that proline, a highly abundant amino...
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Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on stearoyl-CoA desaturase
Metabolic reprogramming is a key hallmark of cancer, but less is known about metabolic plasticity of the same tumor at different sites. Here, we investigated the metabolic adaptation of leukemia in two differe...
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Open Access2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer
Despite the clinical success of Androgen Receptor (AR)-targeted therapies, reactivation of AR signalling remains the main driver of castration-resistant prostate cancer (CRPC) progression. In this study, we pe...
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Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation
Chronic inflammation is linked to diverse disease processes, but the intrinsic mechanisms that determine cellular sensitivity to inflammation are incompletely understood. Here, we show the contribution of gluc...
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Open AccessA rapid method for quantifying free and bound acetate based on alkylation and GC-MS analysis
Acetyl-CoA is a key metabolic intermediate with roles in the production of energy and biomass, as well as in metabolic regulation. It was recently found that acetate is crucial for maintaining acetyl-CoA produ...
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Open AccessMetabolic scavenging by cancer cells: when the going gets tough, the tough keep eating
Cancer is fundamentally a disease of uncontrolled cell proliferation. Tumour metabolism has emerged as an exciting new discipline studying how cancer cells obtain the necessary energy and cellular ‘building bl...
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Friendly neighbours feed tumour cells
In pancreatic cancer, neighbouring non-cancerous cells degrade their own proteins through a process called autophagy and release amino acids that are then taken up and used by the cancer cells. See Letter ...
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Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis
Succinate dehydrogenase (SDH) is a heterotetrameric nuclear-encoded complex responsible for the oxidation of succinate to fumarate in the tricarboxylic acid cycle. Loss-of-function mutations in any of the SDH ...
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Open AccessErratum to: The 2014 Beatson international cancer conference: powering the cancer machine
No abstract
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Open AccessQuantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate
Cell growth requires fatty acids for membrane synthesis. Fatty acids are assembled from 2-carbon units in the form of acetyl-CoA (AcCoA). In nutrient and oxygen replete conditions, acetyl-CoA is predominantly ...
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Open AccessThe 2014 Beatson International Cancer Conference: Powering the Cancer Machine
Here, we present a report of the 2014 annual Beatson International Cancer Conference, Glasgow, July 6–9, 2014. The theme was “Powering the Cancer Machine”, focusing on oncogenic signals that regulate metabolic re...
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Correction: Corrigendum: Quantitative flux analysis reveals folate-dependent NADPH production
Nature 510, 298–302 (2014); doi:10.1038/nature13236 In the interests of transparency, we wish to amend the ‘Competing financial interests’ section of our Letter to read: “J.D.R. is the only author with a compe...
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Quantitative flux analysis reveals folate-dependent NADPH production
A metabolomics quantification of NADPH production and consumption fluxes in proliferating mammalian cells reveals that, in addition to canonical pathways such as the oxidative pentose phosphate pathway, NADPH ...
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Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Oncogenic Ras has previously been shown to promote macropinocytosis; here it is demonstrated that this process allows tumour cells to use extracellular proteins to generate amino acids necessary to support tum...
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Open AccessRas-driven cancer cells can scavenge exogenous lipids to support their proliferation
