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Article
Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer
Risk of recurrence and progression of ductal carcinoma in situ (DCIS) to invasive cancer remains uncertain, emphasizing the need for develo** predictive biomarkers of aggressive DCIS.
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Article
Development and external evaluation of predictions models for mortality of COVID-19 patients using machine learning method
To predict the mortality of patients with coronavirus disease 2019 (COVID-19). We collected clinical data of COVID-19 patients between January 18 and March 29 2020 in Wuhan, China . Gradient boosting decision...
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Article
Open AccessDeconvoluting complex correlates of COVID-19 severity with a multi-omic pandemic tracking strategy
The SARS-CoV-2 pandemic has differentially impacted populations across race and ethnicity. A multi-omic approach represents a powerful tool to examine risk across multi-ancestry genomes. We leverage a pandemic...
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Article
Open AccessOccult polyclonality of preclinical pancreatic cancer models drives in vitro evolution
Heterogeneity is a hallmark of cancer. The advent of single-cell technologies has helped uncover heterogeneity in a high-throughput manner in different cancers across varied contexts. Here we apply single-cell...
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Article
Open AccessAssociation between climate variables and pulmonary tuberculosis incidence in Brunei Darussalam
We investigated the association between climate variables and pulmonary tuberculosis (PTB) incidence in Brunei-Muara district, Brunei Darussalam. Weekly PTB case counts and climate variables from January 2001 ...
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Chapter and Conference Paper
Context-Aware Streaming Perception in Dynamic Environments
Efficient vision works maximize accuracy under a latency budget. These works evaluate accuracy offline, one image at a time. However, real-time vision applications like autonomous driving operate in streaming ...
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Article
Open AccessSOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer
SOD1 is known as the major cytoplasmic superoxide dismutase and an anticancer target. However, the role of SOD1 in cancer is not fully understood. Herein we describe the generation of an inducible Sod1 knockout i...
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Article
Open AccessGlobal trends and gaps in research related to latent tuberculosis infection
There is a global commitment to eliminating tuberculosis (TB). It is critical to detect and treat cases of latent TB infection (LTBI), the reservoir of new TB cases. Our study assesses trends in publication of...
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Article
Open AccessColony-stimulating factor (CSF) 1 receptor blockade reduces inflammation in human and murine models of rheumatoid arthritis
CSF-1 or IL-34 stimulation of CSF1R promotes macrophage differentiation, activation and osteoclastogenesis, and pharmacological inhibition of CSF1R is beneficial in animal models of arthritis. The objective of...
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Article
Open AccessTwo distinct groups of porcine enteropathogenic Escherichia coli strains of serogroup O45 are revealed by comparative genomic hybridization and virulence gene microarray
Porcine enteropathogenic Escherichia coli (PEPEC) strains of serogroup O45 cause post-weaning diarrhea and produce characteristic attaching and effacing (A/E) lesions. Most O45 PEPEC strains possess the locus of ...
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Chapter and Conference Paper
Design Collaboration Using IFC
This paper reports a study that has been undertaken as part of an on-going project to examine the capacity of building information modelling (BIM) techniques to support collaborative design in the building ind...
