The topical collection State-of-the-Art Clinical Surgery intends to summarize state-of-the-art approaches for surgical intervention. The aim is to provide an evidence-based reference of surgical methodology that will aid decision making in everyday clinic and also guide readers toward further relevant in-depth clinical content. Techniques from the fields of general, visceral, and endocrine surgery are at the heart of this collection. We look forward to receiving and reviewing your cutting-edge clinical reviews.