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State-of-the-art surgery for hepatocellular carcinoma

  • State-of-the-Art Clinical Surgery
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Abstract

Background

Hepatocellular carcinoma (HCC) is the most commonly diagnosed primary liver tumor with an increasing incidence worldwide. Management of patients with HCC is largely dictated by the presence of cirrhosis, disease stage, underlying liver function, and patient performance status.

Purpose

We provide an update on key aspects of surgical treatment options for patients with HCC.

Results & Conclusions

Liver resection and transplantation remain cornerstone treatment options for patients with early-stage disease and constitute the only potentially curative options for HCC. Selection of patients for surgical treatment should include a thorough evaluation of tumor characteristics and biology, as well as evidence-based use of various available treatment options to achieve optimal long-term outcomes for patients with HCC.

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Authors and Affiliations

  1. 2Nd Department of Propaedeutic Surgery, Laiko General Hospital, National and Kapodistrian University of Athens, Athens, Greece

    Nikolaos Machairas

  2. Department of Surgery, The Ohio State University Wexner Medical Center and James Cancer Hospital and Solove Research Institute, Columbus, OH, USA

    Diamantis I. Tsilimigras & Timothy M. Pawlik

  3. Department of Surgery, The Urban Meyer III and Shelley Meyer Chair for Cancer Research, The Ohio State University, Wexner Medical Center, The James Cancer Hospital and Solove Research Institute, 395 W. 12th Ave., Suite 670, OH, Columbus, USA

    Timothy M. Pawlik

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All authors contributed to the study’s conception and design. Nikolaos Machairas and Diamatis I. Tsilimigras performed material preparation, data collection, and analysis. Nikolaos Machairas and Diamatis I. Tsilimigras wrote the first draft of the manuscript and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Timothy M. Pawlik.

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Machairas, N., Tsilimigras, D.I. & Pawlik, T.M. State-of-the-art surgery for hepatocellular carcinoma. Langenbecks Arch Surg 406, 2151–2162 (2021). https://doi.org/10.1007/s00423-021-02298-3

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