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Polymeric Nanocomposites for Cancer-Targeted Drug Delivery

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Polymeric and Natural Composites

Part of the book series: Advances in Material Research and Technology ((AMRT))

Abstract

Cancer treatment has been a challenge for the medical science throughout the years. The conventional therapies present several limitations and drawbacks; thus, there is a necessity for new therapeutical approaches. Nanosystems based on polymeric nanocomposites have been described as promising carriers for efficient drug delivery. These systems enhance drug stability in biological fluids providing sustained and controlled release and when biofunctionalized with ligands attached to their shells they can target the treatment specifically to cancer cells. In this chapter, our main interest will be on polymeric nanocomposites for cancer-targeted drug delivery, their efficacy and impact on cancer therapy and multiscale molecular simulation studies for nanostructured polymer systems.

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Abbreviations

α-CD:

Α-cyclodextrin

ADCs:

Antibody-drug conjugates

Ag:

Silver

ALK:

Anaplastic lymphoma kinase

AuNR:

Gold nanorod

BBB:

Blood brain barrier

BD:

Brownian dynamics

BRAF:

V-raf murine sarcoma viral oncogene homolog B1

BRCA:

Breast cancer gene

BRD4:

Bromodomain containing 4

BTB:

Brain tumor barrier

CDK4/6:

Cyclin-dependent kinase

CDK7:

Cyclin-dependent kinase 7

CS:

Chitosan

CSCs:

Cancer stem cells

CT:

Chemotherapy

CTS:

Chondroitin sulphate

DDFT:

Dynamic density functional theory

DOX:

Doxorubicin

DPD:

Dissipative particle dynamics

EGFR:

Epidermal growth factor receptor

FEM:

Finite element method

FDM:

Finite difference method

FVM:

Finite volume method

GO:

Graphene-oxide

HATs:

Histone acetyltransferases

HDACs:

Histone deacetylases

HDIs:

Histone deacetylase inhibitors

HER2:

Human epidermal growth factor receptor 2

IGF-1:

Insulin-like growth factor-1

IONPs:

Iron oxide NPs

LB:

Lattice Boltzmann

LOI:

Loss of imprinting

mTOR:

Mammalian target of rapamycin

MET:

Hepatocyte growth factor receptor

MD:

Molecular dynamics

MC:

Monte Carlo

MTX-PEG:

Methotrexate-PEG

NIR:

Near-infrared radiation

NK:

Natural killer

NP:

Nanoparticle

NSCLC:

Non-small cell lung carcinoma

NTRK:

Neurotrophic receptor tyrosine kinase

PAA:

Poly (acrylic acid)

PARP:

Poly (ADP-ribose) polymerase

PCL:

Polycaprolactone

PD-1:

Programmed cell death protein 1

PD-L1:

Programmed cell death protein 1-ligand

PDMS:

Poly(N-isopropylacrylamide)-metal NPs

PEG:

Poly (ethyleneglycol)

PEI:

Poly(ethylene imine)

PGA:

Poly (glutamic acid)

PI3K:

Phosphatidylinositol 3-kinase

PLGA:

Poly (lactic-co-glycolic acid)

PLLA:

Poly-l-lactic acid

PMMA:

Poly (methyl methacrylate),

pNIPAM:

Poly(N-isopropylacrylamide)

PS:

Polystyrene

PTT:

Photothermal therapy

PTX:

Paclitaxel

PU:

Polyurethane

PVA:

Polyvinyl alcohol

PVDF:

Polyvinylidene fluoride

QM:

Quantum mechanics

RGD peptide:

Arginylglycylaspartic

ROS:

Reactive oxygen species

RT:

Radiotherapy

SEs:

Super-enhancers

SHH:

Sonic hedgehog signalling molecule

TDGL:

Time-dependent Ginzburg–Landau

VEGF:

Vascular endothelial growth factor

WS2-NT-CM-PEI:

Tungsten disulphide nanotubes-ceric ammonium nitrate-PEI

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Authors and Affiliations

  1. Laboratory of Genetic Toxicology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil

    Luiza Steffens Reinhardt & Dinara Jaqueline Moura

  2. Biosciences Research Institute, Athlone Institute of Technology, Athlone, Co. Westmeath, Ireland

    Mabilly Cox Holanda de Barros Dias & Neil J. Rowan

  3. Chemistry Institute, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

    Jussania Gnoatto

  4. Department of Biochemistry and Molecular Biology, Medical University of Lublin, Lublin, Poland

    Anna Wawruszak & Marta HaƂasa

  5. Department of Bioengineering, University of California, Riverside, USA

    Pablo Ricardo Arantes

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  1. Luiza Steffens Reinhardt
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  8. Dinara Jaqueline Moura
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Correspondence to Luiza Steffens Reinhardt .

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  1. Department of Pharmacy, Palamau Institute of Pharmacy, Daltonganj, Jharkhand, India

    Md Saquib Hasnain

  2. Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj, Odisha, India

    Amit Kumar Nayak

  3. Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia

    Saad Alkahtani

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Reinhardt, L.S. et al. (2022). Polymeric Nanocomposites for Cancer-Targeted Drug Delivery. In: Hasnain, M.S., Nayak, A.K., Alkahtani, S. (eds) Polymeric and Natural Composites. Advances in Material Research and Technology. Springer, Cham. https://doi.org/10.1007/978-3-030-70266-3_8

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