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The Associations Between Opioid Use Disorder and Healthcare-Related Outcomes in Vaso-occlusive Crisis
BackgroundIn patients who experience frequent vaso-occlusive crises (VOC), opioid dependence may be due to a need for pain control as opposed to...
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Safety and efficacy of ketorolac continuous infusion for multimodal analgesia of vaso-occlusive crisis in patients with sickle cell disease
Pain is an hallmark of sickle-cell-related acute clinical manifestations as part of acute vaso-occlusive crisis (VOC). In SCD pain has different...
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Economic and Clinical Burden of Managing Sickle Cell Disease with Recurrent Vaso-Occlusive Crises in the United States
IntroductionThe aim of this study was to describe the clinical complications, treatment use, healthcare resource utilization (HCRU), and costs among...
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Cost-Effectiveness of Lovotibeglogene Autotemcel (Lovo-Cel) Gene Therapy for Patients with Sickle Cell Disease and Recurrent Vaso-Occlusive Events in the United States
Background and ObjectiveGene therapies for sickle cell disease (SCD) may offer meaningful benefits for patients and society. This study evaluated the...
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The Association between Adenotonsillectomy and Frequency of Vaso-Occlusive Crises in Patients with Sickle Cell Disease
Sickle cell disease (SCD) typically manifests in early childhood as attacks of pain known as vaso-occlusive crises. Infection and hypoxemia have been...
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Intravenous Acetaminophen vs Intravenous Diclofenac Sodium in Management of Skeletal Vaso-occlusive Crisis Among Children with Homozygous Sickle Cell Disease: A Randomized Controlled Trial
ObjectiveTo compare the efficacy of intravenous acetaminophen and intravenous diclofenac sodium in the management of skeletal vaso-occlusive crisis...
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The impact of Hydroxyurea on the rates of Vaso–occlusive crises in patients with sickle cell disease in Saudi Arabia: a single–center study
BackgroundVaso–occlusive crises (VOCs) are acute and common painful complication of sickle cell disease (SCD), and are the main reason behind the...
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A systematic literature review of frequency of vaso-occlusive crises in sickle cell disease
Background and purposeSickle cell disease (SCD) is a collection of rare inherited blood disorders affecting approximately 100,000 people in the U.S....
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“The project did not come to us with a solution”: Perspectives of research teams on implementing a study about electronic health record-embedded individualized pain plans for emergency department treatment of vaso-occlusive episodes in adults with sickle cell disease
BackgroundThis study aimed to capture the implementation process of the ALIGN Study, (An individualized Pain Plan with Patient and Provider Access...
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Timing matters: An analysis of the relationship between red cell transfusion timing and hospitalization outcomes in sickle cell crisis patients using the National Inpatient Sample database
Vaso-occlusive pain crisis is a debilitating complication of sickle cell disease (SCD) and it is the most common cause of hospitalization among...
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Outcomes related to intravenous fluid administration in sickle cell patients during vaso-occlusive crisis
While fluid replacement therapy is a primary treatment modality used in vaso-occlusive crises for sickle cell disease, data is limited on its safety,...
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Evaluation of the relationship between intravascular hemolysis and clinical manifestations in sickle cell disease: decreased hemopexin during vaso-occlusive crises and increased inflammation in acute chest syndrome
The aims of this study were to determine the possible relationships between the levels of hemin, hemopexin, acid sphingomyelinase, nitrite/nitrate...
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Age-related differences in risks and outcomes of 30-day readmission in adults with sickle cell disease
BackgroundLiterature on 30-day readmission in adults with sickle cell disease (SCD) is limited. This study examined the overall and age-stratified...
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Evaluation of cardiac fibrosis and subclinical cardiac changes in children with sickle cell disease using magnetic resonance imaging, echocardiography, and serum galectin-3
BackgroundMyocardial fibrosis has recently been proposed as one of the contributing factors to the diverse pathogenicity of cardiomyopathy in sickle...
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Jaundice in a Child with Sickle Cell Anemia: A Case Based Approach
Sickle cell anemia (SCA) is an autosomal recessive disorder caused by a mutation in beta globin gene. Hepatobiliary system is affected in 10-40% of...
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Contrast-enhanced CT evaluation of intra-abdominal vessels in sickle cell anemia
BackgroundSickle cell anemia (SCA) is a hereditary hematological disorder that affects millions of people worldwide. Abdominal crisis can result in...
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Death due to sickle cell crisis: a case report
Sickle cell disease (SCD) is the most common hereditary hemoglobinopathy worldwide. It results in characteristic acute and chronic findings on...
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Association of plasma homocysteine level with vaso-occlusive crisis in sickle cell anemia patients of Odisha, India
Vascular complications of sickle cell anemia (SCA) are influenced by many factors. Elevated plasma homocysteine (Hcy) is supposed to be an...
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Haemoglobinopathies and other rare anemias in Spain: ten years of a nationwide registry (REHem-AR)
REHem-AR was created in 2013. The progressive implementation of neonatal screening for haemoglobinopathies in Spanish autonomous communities where...
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Apadamtase Alfa: First Approval
Apadamtase alfa (ADAMTS13, recombinant-krhn; ADZYNMA), a human recombinant form of a disintegrin and metalloproteinase with thrombospondin motifs 13...
