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Management of an incompetent mid-second (mid-2nd) trimester absent ecto-cervix: a case series. Cervical amplification pre-cerclage insertion
BackgroundCervical cerclage is a treatment for an incompetent cervix, the latter being a contributor to spontaneous preterm birth. There is...
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Role of MRI radiomics for the prediction of MYCN amplification in neuroblastomas
ObjectivesWe evaluate MR radiomics and develop machine learning–based classifiers to predict MYCN amplification in neuroblastomas.
Methods ...
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Pre-operative MRI radiomics model non-invasively predicts key genomic markers and survival in glioblastoma patients
PurposeAlthough glioblastoma (GBM) is the most common primary brain malignancy, few tools exist to pre-operatively risk-stratify patients by overall...
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Superior semicircular canal dehiscence postoperative outcomes: a case series of 350 repairs
BackgroundSuperior Semicircular Canal Dehiscence (SSCD) is a dehiscence of the otic capsule which normally lies over the superior semicircular canal....
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Imaging predictors of 4q12 amplified and RB1 mutated glioblastoma IDH-wildtype
IntroductionRecent studies have identified that glioblastoma IDH-wildtype consists of different molecular subgroups with distinct prognoses. In order...
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Optimizing reirradiation for relapsed medulloblastoma: identifying the ideal patient and tumor profiles
BackgroundFirst-line therapies for medulloblastoma(MBL) are obtaining higher survival-rates while decreasing late-effects, but treatment at relapse...
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CT-based morphologic and radiomics features for the classification of MYCN gene amplification status in pediatric neuroblastoma
PurposeMYCN onco-gene amplification in neuroblastoma confers patients to the high-risk disease category for which prognosis is poor and more...
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Comparison of HercepTest™ mAb pharmDx (Dako Omnis, GE001) with Ventana PATHWAY anti-HER-2/neu (4B5) in breast cancer: correlation with HER2 amplification and HER2 low status
Performance of the new CE-IVD-marked HercepTest™ mAb pharmDx (Dako Omnis) assay (HercepTest (mAb)) was compared against the PATHWAY® anti-HER-2/neu...
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Morphometric Analysis of Temporal Bone Radiology for Cochlear Implant Candidacy
Cochlear Implantation (CI) is a well-accepted treatment for severe-to-profound sensorineural hearing loss, refractory to conventional hearing...
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KRD vs. VRD as induction before autologous hematopoietic progenitor cell transplantation for high-risk multiple myeloma
Bortezomib, lenalidomide, and dexamethasone (VRD) induction is standard prior to autologous hematopoietic cell transplantation (auto-HCT) in newly...
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Cochlear implantation in children with auditory neuropathy spectrum disorder: an updated systematic review
BackgroundThe goal of managing auditory neuropathy spectrum disorder (ANSD) is to restore the children’s ability to discriminate auditory...
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Larotinib in patients with advanced and previously treated esophageal squamous cell carcinoma with epidermal growth factor receptor overexpression or amplification: an open-label, multicenter phase 1b study
BackgroundLarotinib is a new first-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. This open-label, phase 1b study is...
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Von Hippel–Lindau (VHL) disease and VHL-associated tumors in Indian subjects: VHL gene testing in a resource constraint setting
BackgroundVon Hippel–Lindau (VHL) syndrome is a familial cancer syndrome caused by mutations in VHL gene. It is characterized by the formation of...
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Incorporating Radiomics into Machine Learning Models to Predict Outcomes of Neuroblastoma
Neuroblastoma is one of the most common pediatric cancers. This study used machine learning (ML) to predict the mortality and a few other...
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Outcomes of Cochlear Implant Recipient With ANSD: Intra and Post Operative Findings, Progress in Audition and Speech Skills
IntroductionAuditory neuropathy spectrum disorder (ANSD) is a distinct type of SNHL that is characterized by the presence of otoacoustic emissions...
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H3 G34-mutant high-grade gliomas: integrated clinical, imaging and pathological characterisation of a single-centre case series
BackgroundDiffuse hemispheric glioma, H3 G34-mutant, is a novel paediatric tumour type in the fifth edition of the WHO classification of CNS tumours...
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Tumor mutation burden is correlated with response and prognosis in microsatellite-stable (MSS) gastric cancer patients undergoing neoadjuvant chemotherapy
BackgroundNeoadjuvant chemotherapy (NACT) before radical gastrectomy is preferred for locally advanced gastric cancer (GC). However, clinical...
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Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers
Platinum resistance is a clinical challenge in ovarian cancer. Platinating agents induce DNA damage which activate Mre11 nuclease directed DNA damage...
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Extracranial medulloepithelioma: a review of the literature
PurposeMedulloepithelioma is a rare, malignant tumor that typically arises in the periventricular region of the cerebral hemispheres or the ciliary...
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Paternal Age is Negatively Associated with Religious Behavior in a Post-60s But Not a Pre-60s US Birth Cohort: Testing a Prediction from the Social Epistasis Amplification Model
Participation in social behaviors that enhance group-level fitness may be influenced by mutations that affect patterns of social epistasis in human...
