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Biologikatherapie bei schwer erkrankten Patienten mit „NSAID-exacerbated respiratory disease“ und stattgehabter ASS‑Desaktivierung
BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is a type‑2 inflammatory disease of the upper airways, with severe impairment of quality...
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Urinary Leukotriene E4 as a Biomarker in NSAID-Exacerbated Respiratory Disease (N-ERD): a Systematic Review and Meta-analysis
Purpose of ReviewNon-steroidal exacerbated respiratory disease (N-ERD) currently requires aspirin challenge testing for diagnosis. Urinary...
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Respiratory Exposure Tests in Aspirin Exacerbated Respiratory Disease
Purpose of reviewControlled oral provocation test with aspirin is considered the “gold standard” for diagnosing hypersensitivity to NSAIDs...
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A retrospective study on long-term efficacy of intranasal lysine-aspirin in controlling NSAID-exacerbated respiratory disease
PurposeAspirin treatment after desensitization (ATAD) represents an effective therapeutic option suitable for NSAID-exacerbated respiratory disease...
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Mast Cells in Aspirin-Exacerbated Respiratory Disease
Purpose of ReviewAspirin-exacerbated respiratory disease (AERD) is a syndrome of high type 2 inflammation and is known to critically involve mast...
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Immune endoty** and gene expression profile of patients with chronic rhinosinusitis with nasal polyps in the aspirin-exacerbated respiratory disease (AERD) and the non-AERD subgroups
BackgroundChronic Rhinosinusitis (CRS) is a paranasal sinus inflammatory disease and is divided into two subgroups defined as CRS with nasal polyps...
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Acetylsalicylic acid challenge or desensitization in sensitive patients with cardiovascular disease
The use of acetylsalicylic acid (ASA) is problematic in subjects with histories of hypersensitivity reactions (HRs) to it or with cross-reactive...
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Recent Updates in Understanding NSAID Hypersensitivity
Purpose of ReviewTo provide a review of available literature regarding nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity with an emphasis...
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Medical ID use by international patients with Aspirin-Exacerbated Respiratory Disease
BackgroundPatients widely use medical identification (ID) to indicate their food and drug allergies, and chronic medical conditions. One chronic...
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Stellenwert von ASS-Provokationen beim Analgetika-Intoleranz-Syndrom
BackgroundNonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD) is often characterized by a severe course of chronic...
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Toxic retrobulbar neuritis due to recurrent nonsteroidal antiinflammatory drug-exacerbated respiratory disease-based chronic sinusitis in the left sphenoid sinus: a case report
BackgroundAbrupt visual impairment constitutes a medical urgency, necessitating an interdisciplinary diagnostic and therapeutic approach owing to the...
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Aspirin Desensitization in Treatment of Chronic Rhinosinusitis with Nasal Polyposis: Current Protocols and Evidence
Purpose of ReviewAspirin-exacerbated respiratory disease (AERD), or NSAID-exacerbated respiratory disease (NERD), is a heterogeneous inflammatory...
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Hat die ASS-Desaktivierung in Zeiten von Biologika noch einen Stellenwert bei chronischer Rhinosinusitis mit nasaler Polyposis?
The prevalence of analgesic intolerance syndrome (AIS), internationally known as NSAID-exacerbated respiratory disease (NERD), is reported to be...
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Coronary Artery Disease and Aspirin Intolerance: Background and Insights on Current Management
Aspirin is one of the most widely used medications across the global healthcare system and is the foundation in treating ischemic heart disease, as...
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The Role of Allergy in Central Compartment Atopic Disease
Purpose of ReviewCentral compartment atopic disease (CCAD) is a variant of chronic rhinosinusitis with nasal polyps (CRSwNP) that is highly...
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Aspirin Desensitization in NERD in the Era of Biologics: First or Last Resource?
Purpose of the ReviewThe classic treatment of non-steroidal anti-inflammatory drug (NSAID) exacerbated respiratory disease (NERD) includes aspirin...
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Pathophysiological Link Between Chronic Rhinosinusitis and Ear Disease
Purpose of ReviewIn the clinical practice, patients affected by chronic rhinosinusitis (CRS) commonly complain of otologic symptoms. This review aims...
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Diagnostic evaluation of hypersensitivity reactions to arylpropionic acid derivatives: a descriptive observational study focusing on clinical characteristics and potential risk factors in children
BackgroundArylpropionic acid derivatives (APs) are the main triggers of nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity. Data on...
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Risk factors for severe adult-onset asthma: a multi-factor approach
BackgroundThe aim was to identify risk factors for severe adult-onset asthma.
MethodsWe used data from a population-based sample (Adult Asthma in...
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A case of possible anaphylaxis to ASA and structurally unrelated NSAIDs
BackgroundNon-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used classes of medications, and are among the leading causes...
