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The Role of Allergy in Central Compartment Atopic Disease

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Abstract

Purpose of Review

Central compartment atopic disease (CCAD) is a variant of chronic rhinosinusitis with nasal polyps (CRSwNP) that is highly associated with aeroallergen sensitivity. The purpose of this review is to define this relationship and highlight the clinical manifestations and treatment strategies for this condition.

Recent Findings

CCAD presents with polypoid mucosal changes or frank polyps in the central compartment of the nasal cavity, defined as the middle and superior turbinates and the posterior superior nasal septum. These changes can be observed both endoscopically and via imaging. It is more strongly associated with allergic rhinitis than the other subtypes of CRSwNP, with increased allergic symptoms and eosinophilic nasal polyps. Local allergy may also play an important role. Treatment strategies are not yet well-defined, and endoscopic sinus surgery (ESS), nasal steroid or saline irrigation, and allergen immunotherapy are all treatment options.

Summary

CCAD is a develo** but distinct subtype of CRSwNP with a unique presentation, pathophysiology, relationship with allergic rhinitis, and possible therapeutic management compared to other endotypes. Continued research is necessary to further define the treatment options for this disease process to best manage the increasing number of affected patients.

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Data Availability

No datasets were generated or analyzed during the current study.

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Authors and Affiliations

  1. Department of Otolaryngology – Head and Neck Surgery, Emory University, 550 Peachtree Street NE, Medical Office Tower, Suite 1135, Atlanta, GA, 30308, USA

    Khaled A. Altartoor, Georges E. Daoud & Thomas S. Edwards

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  1. Khaled A. Altartoor
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  2. Georges E. Daoud
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Contributions

K.A. and G.D. wrote the main manuscript text and prepared the table and figure. T.E. edited the manuscript text and provided endoscopic and radiographic images. All authors reviewed the manuscript.

Corresponding author

Correspondence to Thomas S. Edwards.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

Competing Interests

No funding was received to assist with the preparation of this manuscript. K.A. and G.D. have no relevant financial or non-financial interests to disclose. T.E. has received research support from Sanofi-Aventis U.S. LLC and Regeneron Pharmaceuticals Inc outside the submitted work.

Financial Disclosures

Khaled A. Altartoor: None.

Georges E. Daoud: None.

Thomas S. Edwards: Research Funding – Sanofi, Regeneron.

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Altartoor, K.A., Daoud, G.E. & Edwards, T.S. The Role of Allergy in Central Compartment Atopic Disease. Curr Treat Options Allergy (2024). https://doi.org/10.1007/s40521-024-00368-7

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