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Transcriptomic analysis of glucosidase II beta subunit (GluIIß) knockout A549 cells reveals its roles in regulation of cell adhesion molecules (CAMs) and anti-tumor immunity
Glucosidase II beta subunit (GluIIß), encoded from PRKCSH , is a subunit of the glucosidase II enzyme responsible for quality control of N-linked...
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Therapeutic Targeting of Epicardial and Cardiac Progenitors in the Heart Regeneration
The epicardium is an essential actor during heart development since its active participation in cardiac cell differentiation via cellular contact and...
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Assembling the Puzzle Pieces. Insights for in Vitro Bone Remodeling
As a highly dynamic organ, bone changes during throughout a person’s life. This process is referred to as ‘bone remodeling’ and it involves two...
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Sources, Characteristics, and Therapeutic Applications of Mesenchymal Cells in Tissue Engineering
Tissue engineering (TE) is a therapeutic option within regenerative medicine that allows to mimic the original cell environment and functional...
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Study of differential effects of TGF-beta3/BMP2 on chondrogenesis in MSC cells by gene microarray data analysis
In order to explore the differential effects of TGF-beta3 and BMP2 on chondrogenesis in mesenchymal stem cells (MSCs), the gene expression profiles...
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Cells derived from murine induced pluripotent stem cells (iPSC) by treatment with members of TGF-beta family give rise to osteoblasts differentiation and form bone in vivo
BackgroundInduced pluripotent stem cells (iPSC) are generated by reprogramming somatic cells into embryonic like state (ESC) using defined factors....
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The conditioned medium from a stable human GDF3-expressing CHO cell line, induces the differentiation of PC12 cells
Members of the transforming growth factor-β (TGF-β) superfamily have significant roles in the regulation of a wide variety of physiological...
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Human Bone Marrow Mesenchymal Stem Cells: A Systematic Reappraisal Via the Genostem Experience
Genostem (acronym for “Adult mesenchymal stem cells engineering for connective tissue disorders. From the bench to the bed side”) has been an...
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Osteo-Promoter Database (OPD) – Promoter analysis in skeletal cells
BackgroundIncreasing our knowledge about the complex expression of genes in skeletal tissue will provide a better understanding of the physiology of...
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Embryonic Salivary Gland Branching Morphogenesis
Salivary submandibular gland (SMG) morphogenesis is regulated by the functional integration of stage-specific growth factor-, cytokine- and...
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TGFβ-Dependent Epithelial-Mesenchymal Transition
The transforming growth factor β (TGFβ) is involved in a whole range of biological functions, from cell growth to cell differentiation and apoptosis....
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Overview of Heart Development
Many current studies in heart development appropriately emphasize identifying new genes or genetic “wiring” In the last 5 years, dozens, if not a...
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Gene disruption in mice: Models of development and disease
Gene targeting technology in mice by homologous recombination has become an important method to generate loss-of-function of genes in a predetermined...