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TGFβ-Dependent Epithelial-Mesenchymal Transition

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Rise and Fall of Epithelial Phenotype

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

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Abstract

The transforming growth factor β (TGFβ) is involved in a whole range of biological functions, from cell growth to cell differentiation and apoptosis. The role of TGFβ in epithelial-mesenchymal-transitions (EMTs) has been shown for both embryonic development and tumorigenesis. All three TGFβ mammalian isoforms-TGFβl, TGFβ2 and TGFββcan regulate EMTs, with distinct outcomes depending on the tissue and on the state of cell differentiation. This diversity in the TGFβ response relies on a complex network of signals starting with different sets of TGFβ receptors and subsequently involving distinct TGFβ-dependent pathways. The purpose of this review is to recapitulate the current knowledge on the various signaling pathways—including the Smads, Ras, p38MAPK, RhoA and PI3K-which, upon activation by TGFβ can together give rise to TGFβ—induced EMT phenotypes.

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Authors and Affiliations

  1. Institut de Genetique Moleculaire de Montpellier, CNRS, Montpellier Cedex, France

    Marie-Luce Vignais & Patrick Fafet

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  1. Marie-Luce Vignais
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  2. Patrick Fafet
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Vignais, ML., Fafet, P. (2005). TGFβ-Dependent Epithelial-Mesenchymal Transition. In: Rise and Fall of Epithelial Phenotype. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-28671-3_15

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