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A deep learning model of tumor cell architecture elucidates response and resistance to CDK4/6 inhibitors
Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6is) have revolutionized breast cancer therapy. However, <50% of patients have an objective...
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Punch-excised explants of bovine mammary gland to model early immune response to infection
BackgroundMammary gland (MG) infections (mastitis) are frequent diseases of dairy cows that affect milk quality, animal welfare and farming...
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Porcine lung tissue slices: a culture model for PRCV infection and innate immune response investigations
Respiratory coronaviruses (RCoVs) significantly threaten human health, necessitating the development of an ex vivo respiratory culture system for...
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DeepAEG: a model for predicting cancer drug response based on data enhancement and edge-collaborative update strategies
MotivationThe prediction of cancer drug response is a challenging subject in modern personalized cancer therapy due to the uncertainty of drug...
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Synergistic Effect of Maternal Micronutrient Supplementation on ORFV DNA Vaccine Immune Response in a Pregnant Model
Contagious ecthyma is a contagious zoonotic disease caused by the Orf virus that can infect farm animals and humans, but no vaccine is available for...
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A new scaffold-free tumoroid model provides a robust preclinical tool to investigate invasion and drug response in Renal Cell Carcinoma
Clear cell Renal Cell Carcinoma (ccRCC) is one of the most prevalent kidney cancers, which is often asymptomatic and thus discovered at a metastatic...
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A hierarchical Bayesian model to monitor pelagic larvae in response to environmental changes
European anchovies and round sardinella play a crucial role, both ecological and commercial, in the Mediterranean Sea. In this paper, we investigate...
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Stability of a diffusive-delayed HCV infection model with general cell-to-cell incidence function incorporating immune response and cell proliferation
In this work, we analyse the dynamics of a five-dimensional hepatitis C virus infection mathematical model including the spatial mobility of...
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Protective Effects of Peroxiredoxin 6 in Pro-Inflammatory Response Model Using Raw 264.7 Macrophages
AbstractThe aim of the work was to study effects of peroxiredoxin 6 (PRDX6), a recombinant antioxidant protein, on the level of pro-inflammatory...
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A prognostic model based on tumor microenvironment-related lncRNAs predicts therapy response in pancreatic cancer
Pancreatic cancer is an aggressive malignant tumor with high mortality and a low survival rate. The immune and stromal cells that infiltrate in the...
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A novel molecular subtypes and risk model based on inflammatory response-related lncrnas for bladder cancer
BackgroundInflammation and long noncoding RNAs (lncRNAs) are gradually becoming important in the development of bladder cancer (BC). Nevertheless,...
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Development of a risk model based on autophagy-related genes to predict survival and immunotherapy response in ovarian cancer
BackgroundAutophagy is a highly conserved cellular proteolytic process that can interact with innate immune signaling pathways to affect the growth...
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Optimal treatment placement for on-farm experiments: pseudo-Bayesian optimal designs with a linear response plateau model
On-farm experiments are increasingly being used as their costs have decreased with technological advances in collecting, storing, and processing...
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Unfolded Protein Response in Arabidopsis
The unfolded protein response (UPR) is a highly regulated signaling pathway that is largely conserved across eukaryotes. It is essential for cell...
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Lead Acetate-Injected Mice is an Animal Model for Extrapolation of Calcifying Response to Humans Due to Low Involvement of Bone Resorption
Vascular calcification affects the prognosis of patients with renal failure. Bisphosphonates are regarded as candidate anti-calcifying drugs because...
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Aotus nancymaae model predicts human immune response to the placental malaria vaccine candidate VAR2CSA
Placental malaria vaccines (PMVs) are being developed to prevent severe sequelae of placental malaria (PM) in pregnant women and their offspring. The...
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Modelling the response of common carp (Cyprinus carpio) to natural and managed flows using a stochastic population model
Common carp ( Cyprinus carpio ; hereafter carp) is a highly invasive freshwater fish that has colonised river basins across the world causing...
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DualGCN: a dual graph convolutional network model to predict cancer drug response
BackgroundDrug resistance is a critical obstacle in cancer therapy. Discovering cancer drug response is important to improve anti-cancer drug...
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Long-term antigen-specific immune response by an oncolytic adenovirus encoding SP-SA-E7-4-1BBL in HPV-16 cancer model
BackgroundTo describe an oncolytic adenovirus (OAd) encoding SP-SA-E7-4-1BBL that is capable of inducing tumor regression in therapeutic assays....
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Evaluation of Sugarcane Yield Response to a Phosphate-Solubilizing Microbial Inoculant: Using an Aerial Imagery-Based Model
The use of microbial inoculants has become an effective alternative for increasing crop yields, reducing production costs, and improving...
