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Development of supramolecular anticoagulants with on-demand reversibility
Drugs are administered at a dosing schedule set by their therapeutic index, and termination of action is achieved by clearance and metabolism of the...
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Ex vivo anticoagulants affect human blood platelet biomechanics with implications for high-throughput functional mechanophenoty**
Inherited platelet disorders affecting the human platelet cytoskeleton result in increased bleeding risk. However, deciphering their impact on...
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Murine Models in the Evaluation of Heparan Sulfate-Based Anticoagulants
Evaluating prospective anticoagulant therapies in animal thrombosis and bleeding models are standard pre-clinical approaches. Mice are frequently...
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Effect of heparin and EDTA as anticoagulants on hematological values in farmed juvenile of Arapaima gigas
The rapid coagulation of fish blood makes the use of anticoagulants in hematological analysis necessary and means that choosing the most appropriate...
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Safety outcomes of direct oral anticoagulants in older adults with atrial fibrillation: a systematic review and meta-analysis of (subgroup analyses from) randomized controlled trials
Balancing stroke prevention and risk of bleeding in patients with atrial fibrillation (AF) is challenging. Direct oral anticoagulants (DOACs) are by...
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The impacts of different anticoagulants and long-term frozen storage on multiple metal concentrations in peripheral blood: a comparative study
It is important but remains unclear whether ethylenediaminetetraacetic acid (EDTA) and sodium heparin anticoagulants have different impacts on the...
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Comparative study of hematological parameters of Colossoma macropomum anesthetized with benzocaine and eugenol by using different anticoagulants
The objective of the present study was to evaluate the action of benzocaine and eugenol over anesthesia stages and the use of three anticoagulants...
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Mutations of the VCORC1 Gene of Resistance to Anticoagulants in Synanthropic Rodents in Urbanized Areas of Russia
AbstractThis is the first study to analyze the variability of two exons (the 1st and 3rd) of the VCORC1 gene in Russian populations of mice and...
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Low Level of Resistance to Anticoagulant Rodenticides in the Vkorс1 Gene in House Mice (Mus musculus) and Norway Rats (Rattus norvegicus) in Russia
AbstractGenetic resistance to anticoagulants caused by mutations in the Vkorc1 gene of the most invasive rodent species—Norway rats and house mice,...
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Less brodifacoum in baits results in greater accumulation in the liver of captive Rattus norvegicus in a no-choice trail
Anticoagulants are widely used as potent cumulative rodenticides; however, they are also associated with adverse environmental effects, such as...
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An Unusual Presentation of Superior Mesenteric Venous Occlusion in Mild COVID-19
SARS-CoV-2, an etiological agent of COVID-19, has been reported to inflict remarkably diverse manifestations in different subjects across the globe....
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Current and Future Engineering Strategies for ECMO Therapy
Extracorporeal membrane oxygenation (ECMO) is a last resort therapy for patients with respiratory failure where the gas exchange capacity of the lung...
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Association between lipoprotein(a) and thromboembolism in patients with non-valvular atrial fibrillation: a cross-sectional study
BackgroundLipoprotein(a) [Lp(a)] is a recognized risk factor for ischemic stroke (IS); however, its role in thromboembolism in patients with...
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Artifacts
This chapter deals with the artifacts that can occur during cytometric analyses, highlighting the so-called escapees and debris phenomena. It then...
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Rodenticides and Wildlife Extermination
AbstractContamination with the chemical products used in agricultural activities is the largest human food safety problem, but their use cannot be...
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Immunothrombotic dysregulation in chagas disease and COVID-19: a comparative study of anticoagulation
Chagas and COVID-19 are diseases caused by Trypanosoma cruzi and SARS-CoV-2, respectively. These diseases present very different etiological agents...
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Comparative study of different anticoagulants and coagulants in the evaluation of clinical application of platelet-rich plasma (PRP) standardization
To investigate the impact of different anticoagulants and coagulants with autologous platelet-rich plasma (PRP) in order to evaluate the clinical...
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Spatial Metabolomics Reveals the Multifaceted Nature of Lamprey Buccal Gland and Its Diverse Mechanisms for Blood-Feeding
Lampreys are blood-sucking vampires in marine environments. From a survival perspective, it is expected that the lamprey buccal gland exhibits a...
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Modern Rodenticides and Nontarget Species
Abstract —It is generally recognized that environmental pollution with agrotechnical substances is a major problem for the conservation of biological...