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Is Fructose the Problem?
Table sugar (sucrose) is a combination of two simple sugars, glucose and fructose. Robert Lustig suggested that obesity is in particular a response...
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Bioactive Compounds and Biological Activities of Korean Ginseng (Panax ginseng Meyer)
Panax ginseng is a perennial herb that has been widely used as a medicinal plant in Southeast Asia and recently in Western medicine. It contains...
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Fructose: a modulator of intestinal barrier function and hepatic health?
PurposeConsumption of fructose has repeatedly been discussed to be a key factor in the development of health disturbances such as hypertension,...
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Coffee leaf extract exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced C57BL6 obese mice
In the present study, the effect of coffee leaf extract (CLE) on in vitro enzyme inhibition was studied. Furthermore, its impact on the high-fat diet...
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Malvidin: Advances in the Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology
Malvidin is an O-methylated anthocyanidin, the 3′,5′-methoxy derivative of delphinidin responsible for the blue-red color found in flowers and...
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Next-Generation Therapies for Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM), which has been considered a pandemic due to its growing pervasiveness in the world population, is associated with...
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Supplementation of non-fermented and fermented goji berry (Lycium barbarum) improves hepatic function and corresponding lipid metabolism via their anti-inflammatory and antioxidant properties in high fat-fed rats
Development of obesity is associated with excessive fat accumulation and oxidative stress along with chronic inflammation. Goji berries ( Lycium...
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Long-term dietary DHA intervention prevents telomere attrition and lipid disturbance in telomerase-deficient male mice
PurposePrevious evidence indicated anti-ageing potential of docosahexaenoic acid (DHA), but the underlying mechanism remains unclear. We investigated...
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Fish oil supplementation during pregnancy decreases liver endocannabinoid system and lipogenic markers in newborn rats exposed to maternal high-fat diet
PurposeMaternal high-fat diet (HF) programs obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), hypertriglyceridemia, and...
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Novel evolved Yarrowia lipolytica strains for enhanced growth and lipid content under high concentrations of crude glycerol
BackgroundYarrowia lipolytica is a well-studied oleaginous yeast known for its ability to accumulate and store intracellular lipids, while growing...
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The Bright and Dark Sides of Wheat
Wheat is a worldwide staple food for centuries. However, several debates and questions about the effect of wheat intake versus human health started...
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Antihypertriglyceridemia activities of naturally fermented green tea, Heukcha, extract through modulation of lipid metabolism in rats fed a high-fructose diet
Hypertriglyceridemia, a symptom of elevated triglyceride level in the blood, is a potent risk factor for cardiovascular and metabolic disorders....
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Sorghum flour BRS 305 hybrid has the potential to modulate the intestinal microbiota of rats fed with a high-fat high-fructose diet
AimThe present study aimed to investigate the effect of dry heated whole sorghum BRS 305 hybrid flour on the gut microbiota modulation and gut health...
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Advances in Nanoencapsulated Phytomedicines (Phytochemicals and Their Extracts) for the Treatment of Obesity, Diabetes, and Their Associated Complications
In traditional medicine of different countries, several herbal formulations are prescribed for the treatment of obesity, diabetes, and its associated...
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Functional Teas from Penthorum chinense Pursh Alleviates Ethanol-Induced Hepatic Oxidative Stress and Autophagy Impairment in Zebrafish via Modulating the AMPK/p62/Nrf2/mTOR Signaling Axis
Penthorum chinense Pursh (PCP), a medicinal and edible plant, is widely used in many clinical liver diseases. Oxidative stress and autophagy...
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Bioactive Compounds and Biological Activities of Korean Ginseng (Panax ginseng Meyer)
Panax ginseng is a perennial herb that has been widely used as a medicinal plant in Southeast Asia and recently in Western medicine. It contains...
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New Sulfur-Containing Diketopiperazine from Marine-Derived Bacteria Streptomyces rochei sp. 81 with Potent Carbonic Anhydrase II Inhibition
The ethyl acetate extract of the marine bacterial strain Streptomyces rochei sp. 81 was purified by silica gel column chromatography to obtain three...
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Hepatoprotective Effect of Trehalose: Insight into Its Mechanisms of Action
Trehalose is a nonreducing disaccharide formed by two glucose molecules. It has been shown that trehalose can protect proteins and cellular membranes...
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Sesamol Alleviates High-Fat Diet-Induced Hepatic Insulin Resistance in C57BL/6 J Mice Through AMPK Activation Mediated by Adipose Adiponectin
Sesamol is the major bioactive constituent isolated from sesame seeds and has a variety of bioactivities. However, its role and mechanism in liver...
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Cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis
BackgroundExtracellular vesicles (EVs) are recognized as novel cell-free therapeutics. Non-alcoholic steatohepatitis (NASH) remains a critical health...
