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Antihypertriglyceridemia activities of naturally fermented green tea, Heukcha, extract through modulation of lipid metabolism in rats fed a high-fructose diet

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Abstract

Hypertriglyceridemia, a symptom of elevated triglyceride level in the blood, is a potent risk factor for cardiovascular and metabolic disorders. Among the numerous treatments to regulate circulating triglyceride levels, fibrates are widely used to treat hypertriglyceridemia, although they also have side effects such as hepatotoxicity and gallstone formation. In the present study, we aimed to investigate the blood triglyceride-lowering effects of a naturally fermented green tea extract (NFGT) and the underlying mechanisms on hypertriglyceridemia in vitro and in vivo models. NFGT suppressed the expression of lipogenic genes, while augmented expression of fatty acid oxidation-related genes in cultured cells, leading to the significant decrease of intracellular triglyceride content. NFGT treated group in fructose-induced hypertriglyceridemic rat model significantly decreased plasma and hepatic triglyceride, which was accompanied by an increase in excretion of fecal fat. Taken together, we propose that NFGT could be potentially a novel functional ingredient to prevent or treat hypertriglyceridemia.

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Acknowledgements

We appreciate the important discussion and helpful advice from Dr. **-Oh Chung (AmorePacific) and Dr. Min-Seuk Lee (Osulloc Farm). We also acknowledge Kiyeop Park (Aestura Corporation) for technical assistance in animal experiments.

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Authors and Affiliations

  1. Healthcare Research Division, AMOREPACIFIC R&D Center, Yongin, Republic of Korea

    Hyun Woo Jeong, Ji-Hae Lee, Chan-Su Rha, Jaehong Park & Miyoung Park

  2. QA Team, Aestura Corporation, Ansung, Republic of Korea

    ** Kyu Choi

  3. Osulloc R&D Center, Osulloc Farm Corporation, Jeju, Republic of Korea

    Jung Dae Lee

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  1. Hyun Woo Jeong
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  2. Ji-Hae Lee
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  3. ** Kyu Choi
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Correspondence to Miyoung Park.

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Jeong, H.W., Lee, JH., Choi, J.K. et al. Antihypertriglyceridemia activities of naturally fermented green tea, Heukcha, extract through modulation of lipid metabolism in rats fed a high-fructose diet. Food Sci Biotechnol 30, 1581–1591 (2021). https://doi.org/10.1007/s10068-021-00992-y

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