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Evaluation of Mesenteric Microvascular Hyperpermeability Following Hemorrhagic Shock Using Intravital Microscopy
Intravital microscopy is a powerful tool for evaluating vascular hyperpermeability in various vascular beds. Hemorrhagic shock after traumatic injury...
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Intravital Imaging of Leukocyte-Endothelial Interaction in Hindlimb Ischemia/Reperfusion Injury by Intravital Multiphoton Microscopy
Ischemia/reperfusion injury in skeletal muscle leads to sterile inflammation and affects structure and function permanently. However, the main...
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Determination of Blood-Brain Barrier Hyperpermeability Using Intravital Microscopy
The blood vessels that vascularize the central nervous system (CNS) exhibit unique properties, termed the blood-brain barrier (BBB). The BBB allows...
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Cancer Imaging by Intravital Microscopy: The Dorsal Window Chamber Model
Intravital microscopy allows a direct visualization of cells’ behavior in their environment in a living organism with all its complexity. With...
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Intravital Microscopy of the Metastatic Pulmonary Environment
Real-time in vivo imaging has become an integral tool for the investigation and understanding of cellular processes in health and disease at...
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Intravital three-photon microscopy allows visualization over the entire depth of mouse lymph nodes
Intravital confocal microscopy and two-photon microscopy are powerful tools to explore the dynamic behavior of immune cells in mouse lymph nodes...
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Intravital Microscopy to Study the Effect of Matrix Metalloproteinase Inhibition on Acute Myeloid Leukemia Cell Migration in the Bone Marrow
Hematopoiesis is the process through which all mature blood cells are formed and takes place in the bone marrow (BM). Acute myeloid leukemia (AML) is...
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Intravital imaging of immune responses in intestinal inflammation
To date, many kinds of immune cells have been identified, but their precise roles in intestinal immunity remain unclear. Understanding the in vivo...
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Intravital Imaging of Regulatory T Cells in Inflamed Skin
Regulatory T cells play key roles in skin homeostasis and inflammation and in regulating antitumor responses. Understanding of the biology of this...
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Landmark-based retrieval of inflamed skin vessels enabled by 3D correlative intravital light and volume electron microscopy
The nanometer spatial resolution of electron microscopy imaging remains an advantage over light microscopy, but the restricted field of view that can...
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Assessment of the In Vivo Response to Nanobody-Targeted PDT Through Intravital Microscopy
Methods that allow real-time, longitudinal, intravital detection of the fluorescence distribution and the cellular and vascular responses within...
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Intravital measurements of solid stresses in tumours reveal length-scale and microenvironmentally dependent force transmission
In cancer, solid stresses impede the delivery of therapeutics to tumours and the trafficking and tumour infiltration of immune cells. Understanding...
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Intravital imaging to study cancer progression and metastasis
Navigation through the bulk tumour, entry into the blood vasculature, survival in the circulation, exit at distant sites and resumption of...
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Integrated data from intravital imaging and HPLC–MS/MS analysis reveal large interspecies differences in AFB1 metabolism in mice and rats
Large interspecies differences between rats and mice concerning the hepatotoxicity and carcinogenicity of aflatoxin B 1 (AFB 1 ) are known, with mice...
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Contribution of Intravital Neuroimaging to Study Animal Models of Multiple Sclerosis
Multiple sclerosis (MS) is a complex and long-lasting neurodegenerative disease of the central nervous system (CNS), characterized by the loss of...
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Analysis of ischemic stroke-mediated effects on blood–brain barrier properties along the arteriovenous axis assessed by intravital two-photon imaging
Early breach of the blood–brain barrier (BBB) and consequently extravasation of blood-borne substances into the brain parenchyma is a common hallmark...
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Intravital Microscopy Imaging of Invariant Natural Killer T-Cell Dynamics in the Liver Using CXCR6-eGFP Transgenic Mice
The immune response in the liver is a highly dynamic process involving the recruitment of many types of immune cells. As a powerful imaging...
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Intravital Imaging Reveals the Ameliorating Effect of Colchicine in a Photothrombotic Stroke Model via Inhibition of Neutrophil Recruitment
Although post-stroke neutrophil recruitment is known to be deleterious to neural tissues in the peri-infarct area, the precise behavior of recruited...
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Intravital Imaging of Brain Tumors
Intravital imaging on live animals has provided new insights into the dynamics of tumor cells within their orthotopic microenvironment. In this...
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Intravital Microscopy: A Tool to Investigate the Toxicity in the Immune System , Vessel Rheology , and Xenobiotic Distribution
Intravital microscopy (IVM) is an essential experimental approach for evaluating, in real time, cell interactions in the blood and rheological...