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Effects of telmisartan and perindopril combination on hypertension and cardiovascular damage
PurposeCombined therapy is considered when monotherapy fails to control blood pressure (BP). This study evaluated the effects of combined treatment...
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Perindopril ameliorates experimental Alzheimer’s disease progression: role of amyloid β degradation, central estrogen receptor and hyperlipidemic-lipid raft signaling
Accumulating evidence indicates that over-stimulation of angiotensin-converting enzyme 1 (ACE1) activity is associated with β-amyloid (Aβ) and...
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The Protective Effects of Perindopril Against Acute Kidney Damage Caused by Septic Shock
Acute kidney injury (AKI) resulting from septic shock caused by sepsis is an important health problem encountered at rates of 55–73%. Increasing...
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Molecular mechanisms underlying methotrexate-induced intestinal injury and protective strategies
Methotrexate (MTX) is a folic acid reductase inhibitor that manages various malignancies as well as immune-mediated inflammatory chronic diseases....
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Molecular modeling of the interaction of ligands with ACE2–SARS-CoV-2 spike protein complex
COVID-19 is a new communicable disease with a widespread outbreak that affects all populations worldwide triggering a rush of scientific interest in...
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The Renin-Angiotensin System and Cancer
The renin-angiotensin system (RAS), classically known for its role in cardiovascular homeostasis, is increasingly recognized to be dysregulated in...
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Repurposing Marketed Drugs as Antidepressants with In Silico, In Vivo, and In Vitro Screening Methods
Drug repurposing is a strategy to identify new therapeutic uses for marketed drugs, discontinued or shelved drugs, and drug candidates in clinical...
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Renin-Angiotensin System and Cancer: From Laboratory to Clinics
Renin-Angiotensin System (RAS) is a vital system regulating blood pressure and maintaining sodium homeostasis in the human body. It consists of...
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Renin-Angiotensin System in Hematological Malignancies
The regular functioning of the human body is the result of interactions between numerous organs and biological systems, with the Renin-Angiotensin...
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Perindopril regulates the inflammatory mediators, NF-κB/TNF-α/IL-6, and apoptosis in cisplatin-induced renal dysfunction
Cisplatin (CP) is an essential chemotherapeutic drug used over the world against many types of cancer. It has several side effects such as...
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Prophylactic, single-drug cardioprotection in a comparative, experimental study of doxorubicin-induced cardiomyopathy
BackgroundCardiomyopathy is a common side effect of doxorubicin (DOX) chemotherapy. Despite intensive research efforts in the field, there is still...
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Renin Angiotensin System (RAS): The Common Thread Between Cancer and Heart Failure
Cancer is a chronic illness that directly or indirectly affects many individuals worldwide. As the second most commonly diagnosed cancer worldwide,...
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Renin Angiotensin System in the Pathophysiology of Diabetic Cardiomyopathy in Type 2 Diabetes
Type 2 diabetesDiabetes mellitus is associated with a high risk of heart failureHeart failure, in part because of its potential to induce impaired...
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The New Dimension of the Renin-Angiotensin System in the Hallmarks of Cancer
The renin angiotensin-system, its well-known systemic regulation of the systemic pressure and its role in hypertension has been widely studies, but...
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Robust arm and leg muscle adaptation to training despite ACE inhibition: a randomized placebo-controlled trial
PurposeAngiotensin-converting enzyme (ACE) inhibitor treatment is widely applied, but the fact that plasma ACE activity is a potential determinant of...
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A Comprehensive Review of the Impact of the Renin Angiotensin System in the Liver, Lung, Infectious Diseases and Cancers
Renin angiotensin aldosterone system has long been known for its role in the regulation of blood pressure and hydro-electrolyte balance in human...
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Association between angiotensin-converting enzyme inhibitors and the risk of lung cancer: a systematic review and meta-analysis
BackgroundThe association between the use of angiotensin-converting enzyme inhibitors (ACEIs) and lung cancer risk remains controversial. This study...
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The Prevalence of Several Treatments in Preventing the Back Conversion of Acyl Glucuronide Metabolites in Abbreviated New Drug Applications
The bioanalysis of drugs that undergo acyl glucuronidation presents an analytical challenge due to poor stability of acyl glucuronide metabolites in...
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Survivability of patients admitted for stroke in a primary stroke center, Penang, Malaysia: a retrospective 5-year study
BackgroundStroke is one of the most common noncommunicable diseases, with significant public health implications both globally and in Malaysia. The...
