Abstract
The renin angiotensin-system, its well-known systemic regulation of the systemic pressure and its role in hypertension has been widely studies, but this system has also a paracrine function. The RAS was been found to be express in almost every tissue, and there is enough evidence to link it to carcinogenesis and cancer progression. With the purpose of facilitating advances in the study of this disease, Weinberg and Hanahan described a series of cellular characteristics that tumor cells can share, which are known as the Hallmarks of cancer. These are defined as “the distinctive and complementary capacities that cells must acquire during the carcinogenesis process that allow them to survive, proliferate and disseminate”. Originally there were 6, but currently up to 10 are “officially” accepted and 4 new ones were proposed by Hanahan in early 2022. In this chapter we describe how RAS is related to the 10 classical hallmarks of cancer, defined as a series of cellular characteristics that tumor cells can share, but also to the 4 new hallmarks described recently.
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Daza-Galicia, K., Augusto Landetta-Platonoff, J., Wegman-Ostrosky, T. (2023). The New Dimension of the Renin-Angiotensin System in the Hallmarks of Cancer. In: Bhullar, S.K., Tappia, P.S., Dhalla, N.S. (eds) The Renin Angiotensin System in Cancer, Lung, Liver and Infectious Diseases. Advances in Biochemistry in Health and Disease, vol 25. Springer, Cham. https://doi.org/10.1007/978-3-031-23621-1_19
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DOI: https://doi.org/10.1007/978-3-031-23621-1_19
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