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Recurrent Clostridioides difficile Infection: Current Clinical Management and Microbiome-Based Therapies
Clostridioides difficile is one of the most important causes of healthcare-associated diarrhea. The high incidence and recurrence rates of C. difficile ...
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Population plasma and urine pharmacokinetics and the probability of target attainment of fosfomycin in healthy male volunteers
PurposeA population pharmacokinetic model of fosfomycin was developed in healthy volunteers after intravenous administration, and different dosing...
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Dalbavancin as suppressive therapy for implant-related infections: a case series with therapeutic drug monitoring and review of the literature
Implant-related infections may need suppressive antibiotic therapy (SAT). We describe a SAT strategy using dalbavancin with therapeutic drug...
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New Promising Antimicrobials in Development and Novel Approaches for Treatment of Infections
Despite the approval of several new antibiotics in the last several years, there is still an unmet need for treating multidrug-resistant bacteria,...
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Linezolid pharmacokinetics: a systematic review for the best clinical practice
ObjectivesTo summarize the pharmacokinetics of linezolid to optimize the dosing regimen in special populations.
MethodsA literature search was...
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A Multi‑Center, Open‑Label, Single‑Arm Trial to Evaluate the Efficacy, Pharmacokinetics, and Safety and Tolerability of IGSC 20% in Subjects with Primary Immunodeficiency
PurposeThe purpose of this phase 3 study was to evaluate the efficacy, pharmacokinetics (PK), and safety of Immune Globulin Subcutaneous (Human), 20%...
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Resistance in Tuberculosis: Molecular Mechanisms and Modulation
Since the time of years following World War II, tuberculosis (TB) has become a treatable disease due to the discoveryDiscoverydrug of...
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Efficacy of 3-day low dose quinine plus clindamycin versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children (CLINDAQUINE): an open-label randomized trial
BackgroundThe World Health Organization recommends quinine plus clindamycin as first-line treatment of malaria in the first trimester of pregnancy...
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Association of antimicrobial perioperative prophylaxis with cefuroxime plus metronidazole or amoxicillin/clavulanic acid and surgical site infections in colorectal surgery
ObjectiveTo compare intravenous (IV) amoxicillin/clavulanic acid (A/CA) to IV cefuroxime plus metronidazole (C + M) for preventing surgical site...
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The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis
BackgroundThe gut microbiota can affect neurologic disease by sha** microglia, the primary immune cell in the central nervous system (CNS). While...
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Salmonella Typhimurium expressing chromosomally integrated Schistosoma mansoni Cathepsin B protects against schistosomiasis in mice
Schistosomiasis threatens hundreds of millions of people worldwide. The larval stage of Schistosoma mansoni migrates through the lung and adult worms...
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Tazobactam/ceftolozane and tobramycin combination therapy in extensively drug-resistant Pseudomonas aeruginosa infections in severe burn injury: a case report
BackgroundCombination therapy with tazobactam/ceftolozane (TAZ/CTLZ) and high-dose aminoglycosides has been reported to be efficacious in extensively...
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Current state of neuroprotective therapy using antibiotics in human traumatic brain injury and animal models
TBI is a leading cause of death and disability in young people and older adults worldwide. There is no gold standard treatment for TBI besides...
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Formulation, pharmacokinetics, and antibacterial activity of florfenicol-loaded niosome
The growing interest in employing nano-sized pharmaceutical formulations in veterinary medicine has prompted the exploration of the novel...
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Photodynamic Inactivation of Mycobacterium tuberculosis Using Alluminium Phthalocyanine
In a series of in vitro experiments, the optimum regimes of laser treatment were determined for effective photodynamic inactivation of Mycobacterium...
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Potential of Curcumin Nanoparticles in Tuberculosis Management
Tuberculosis (TB), the deadliest infectious-disease caused by Mycobacterium tuberculosis (M.tb) created a global-threat to the entire human race...
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Doxycycline for transgene control disrupts gut microbiome diversity without compromising acute neuroinflammatory response
The tetracycline transactivator (tTA) system provides controllable transgene expression through oral administration of the broad-spectrum antibiotic...
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Nano vs Resistant Tuberculosis: Taking the Lung Route
Tuberculosis (TB) is among the top 10 infectious diseases worldwide. It is categorized among the leading killer diseases that are the reason for the...
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A systematic review of the drug-drug interaction between Statins and Quinolones
BackgroundStatins are widely used in cardiovascular disease (CVD) as a common lipid-lowering drug, while quinolones are widely used for the treatment...
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The Pharmacokinetic and Pharmacodynamic Properties of Antitubercular Medications
PharmacokineticsPharmacokinetics and pharmacodynamicsPharmacodynamics operate in a partnership that can be used to maximize a drug’s potential for...