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  1. No Access

    Article

    Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma

    Head and neck squamous cell carcinoma (HNSCC) includes a subset of cancers driven by human papillomavirus (HPV). Here we use single-cell RNA-seq to profile both HPV-positive and HPV-negative oropharyngeal tumo...

    Sidharth V. Puram, Michael Mints, Ananya Pal, Zongtai Qi, Ashley Reeb… in Nature Genetics (2023)

  2. Article

    Open Access

    Transposase map** identifies the genomic targets of BAP1 in uveal melanoma

    BAP1 is a histone deubiquitinase that acts as a tumor and metastasis suppressor associated with disease progression in human cancer. We have used the “Calling Card System” of transposase-directed transposon in...

    Matthew Yen, Zongtai Qi, Xuhua Chen, John A. Cooper, Robi D. Mitra… in BMC Medical Genomics (2018)

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  3. Article

    Open Access

    Cooperative p16 and p21 action protects female astrocytes from transformation

    Mechanisms underlying sex differences in cancer incidence are not defined but likely involve dimorphism (s) in tumor suppressor function at the cellular and organismal levels. As an example, sexual dimorphism ...

    Najla Kfoury, Tao Sun, Kwanha Yu, Nathan Rockwell… in Acta Neuropathologica Communications (2018)

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  4. No Access

    Protocol

    Pyrosequencing On-Chip Based on a Gel-Based Solid-Phase Amplification

    As conventional solid-phase amplification (SPA) on a two-dimensional slide has a low amplification capacity due to a limited amount of immobilized primers, we propose a three-dimensional SPA by immobilizing pr...

    Huan Huang, Pengfeng **ao, Zongtai Qi… in Advances and Clinical Practice in Pyrosequ… (2016)