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Open AccessGlioblastoma disrupts cortical network activity at multiple spatial and temporal scales
The emergence of glioblastoma in cortical tissue initiates early and persistent neural hyperexcitability with signs ranging from mild cognitive impairment to convulsive seizures. The influence of peritumoral s...
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The Neuroscience of Glioblastoma
While unrestrained cell growth characterizes all cancers, the attributes of the tumor microenvironment or host organ provide unique trophic factors and mechanism towards this growth. Especially for the brain, ...
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Article
PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis
Glioblastoma is a universally lethal form of brain cancer that exhibits an array of pathophysiological phenotypes, many of which are mediated by interactions with the neuronal microenvironment1,2. Recent studies ...
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Article
Open AccessCooperative p16 and p21 action protects female astrocytes from transformation
Mechanisms underlying sex differences in cancer incidence are not defined but likely involve dimorphism (s) in tumor suppressor function at the cellular and organismal levels. As an example, sexual dimorphism ...
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Article
Identification of diverse astrocyte populations and their malignant analogs
The nature of astrocyte diversity in the adult brain has remained poorly defined. The authors identify five astrocyte subpopulations in the brain that exhibit extensive molecular and functional diversity. They...
