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Article
Inhibitory mechanism of lead on transferrin-bound iron uptake by rabbit reticulocytes: A fractal analysis
Experimental data of transferrin and transferrin-bound iron uptake byrabbit reticulocytes in the presence or absence of extracellular lead isanalyzed by means of a fractal model. A highly significant correlati...
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Article
Hydrogen peroxide enhanced inron-induced injury in isolated heart and ventricular cardiomyocyte in rats
To explore the cardiac effects of iron with or without hydrogen peroxide, the isolated perfused rat heart and enzymatically isolated ventricular cardiomyocyte were used. It was shown that treatment with cell-p...
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Article
Genistein protects primary cortical neurons from iron-induced lipid peroxidation
Neuroprotective role of isoflavones in particular genistein might be resulted from their antioxidant activities in addition to their estrogenic actions. In the present study, we investigated effect of genistei...
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Article
Nitric oxide inhibition decreases bleomycin-detectable iron in spleen, bone marrow cells and heart but not in liver in exercise rats
The possible role of nitric oxide on the exercise-induced changes in bleomycin-detectable iron (BDI) in the liver, spleen, bone marrow cells and heart was investigated. Female Sprague—Dawley rats were randomly...
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Article
Molecular analysis of increased iron status in moderately exercised rats
Although iron plays a critical role in exercise, the regulatory mechanism of iron metabolism remains poorly understood. The aims of the present study were to investigate the effects of different intensity exer...
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Article
Ginkgolides protect primary cortical neurons from potassium cyanide-induced hypoxic injury
In this study, we investigated the effects of ginkgolides (Gins A, B, C and J), the main constituent of the non-flavone fraction of EGb 761, on hypoxic injury induced by potassium cyanide (KCN) in primary cort...
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Article
Identification of transcriptionally regulated genes in response to cellular iron availability in rat hippocampus
The present study was attempted to identify transcriptionally regulated genes of the normal neurocytes responsive to iron availability. Postnatal rat hippocampus cells were primarily cultured either under the ...
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Article
Protection against hydrogen peroxide-induced injury by Z-ligustilide in PC12 cells
Z-ligustilide (Z-LIG) is the primary lipophilic compound of the Chinese medicine Danggui (Radix Angelica sinensis). Previous studies demonstrated that Z-LIG had significant neuroprotective potential in both trans...
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Article
Nerve Growth Factor Protects the Cortical Neurons from Chemical Hypoxia-induced Injury
Previous studies showed that nerve growth factor (NGF) exerts protective effects on cultured neurons against various kinds of damage. However, a recent publication reported that exposure of NGF-treated PC12 ce...
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Article
Activation of Group III Metabotropic Glutamate Receptor Reduces Intracellular Calcium in β-Amyloid Peptide [31–35]-Treated Cortical Neurons
It is unknown whether amyloid beta-protein 31–35 (Aβ[31–35]) has effects similar to Aβ[1–40] and Aβ[25–35] on the intracellular calcium ([Ca2+]i) to induce a disruption of calcium homeostasis. In this study, we i...
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Article
A Synergistic Role of Hyperthermic and Pharmacological Preconditioning to Protect Astrocytes Against Ischemia/Reperfusion Injury
Recent studies provide solid evidence for the importance to delineate the co-relationship between preconditioning stimuli and therapeutic efficacy of drugs commonly used in clinic. However, very little is know...
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Article
Angiotensin II Inhibits Iron Uptake and Release in Cultured Neurons
Based on the well-confirmed roles of angiotensin II (ANGII) in iron transport of peripheral organs and cells, the causative link of excess brain iron with and the involvement of ANGII in neurodegenerative diso...
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Article
Iron and Intracerebral Hemorrhage: From Mechanism to Translation
Intracerebral hemorrhage (ICH) is a leading cause of morbidity and mortality around the world. Currently, there is no effective medical treatment available to improve functional outcomes in patients with ICH d...
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Article
Lipopolysaccharides Upregulate Hepcidin in Neuron via Microglia and the IL-6/STAT3 Signaling Pathway
Neuroinflammation is closely related to brain iron homeostasis. Our previous study demonstrated that lipopolysaccharides (LPS) can regulate expression of iron-regulatory peptide hepcidin; however, the mechanis...
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Article
Hepcidin Suppresses Brain Iron Accumulation by Downregulating Iron Transport Proteins in Iron-Overloaded Rats
Iron accumulates progressively in the brain with age, and iron-induced oxidative stress has been considered as one of the initial causes for Alzheimer’s disease (AD) and Parkinson’s disease (PD). Based on the ...
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Article
Open AccessA combination of serum iron, ferritin and transferrin predicts outcome in patients with intracerebral hemorrhage
Association of a high-serum ferritin with poor outcome showed that iron might play a detrimental role in the brain after intracerebral hemorrhage (ICH). Here, we investigated changes in serum iron, ferritin, t...
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Article
CX3CL1/CX3CR1 Axis Plays a Key Role in Ischemia-Induced Oligodendrocyte Injury via p38MAPK Signaling Pathway
Based on current knowledge on the role of the CX3CL1/CX3CR1 axis in the regulation of microglial activation and on the involvement of activated microglia in damaging oligodendrocytes, we hypothesized that CX3C...
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Article
Effects of alpha-lipoic acid on expression of iron transport and storage proteins in BV-2 microglia cells
The antioxidant properties of alpha-lipoic acid (ALA) are associated with its ability to reduce iron in cells and tissues, which is partly due to its inhibiting effect on iron uptake from transferrin and its p...
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Article
Open AccessRefinement of learned skilled movement representation in motor cortex deep output layer
The mechanisms underlying the emergence of learned motor skill representation in primary motor cortex (M1) are not well understood. Specifically, how motor representation in the deep output layer 5b (L5b) is s...
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Article
Expression of Iron Transporters and Pathological Hallmarks of Parkinson’s and Alzheimer’s Diseases in the Brain of Young, Adult, and Aged Rats
Iron accumulates progressively in the brain with age; however, the cause is unknown. We hypothesized that iron accumulation may be associated with the age-induced changes in the expression of iron metabolism p...
