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Article
The paradox of bone mineral density and fracture risk in type 2 diabetes
Fracture risk in type 2 diabetes (T2D) patients is paradoxically increased despite no decrease in areal bone mineraldensity (BMD). This phenomenon, known as the “diabetic bone paradox”, has been attributed to ...
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Article
Open AccessVertebral HU value and the pectoral muscle index based on chest CT can be used to opportunistically screen for osteoporosis
Existing studies have shown that computed tomography (CT) attenuation and skeletal muscle tissue are strongly associated with osteoporosis; however, few studies have examined whether vertebral HU values and th...
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Article
Role of Iron Accumulation in Osteoporosis and the Underlying Mechanisms
Osteoporosis is prevalent in postmenopausal women. The underlying reason is mainly estrogen deficiency, but recent studies have indicated that osteoporosis is also associated with iron accumulation after menop...
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Article
Open AccessEfficacy of Yigu® versus Aclasta® in Chinese postmenopausal women with osteoporosis: a multicenter prospective study
Zoledronic acid (ZOL) is a therapy inhibiting bone resorption. In this study, generic ZOL (Yigu®) showed its clinical efficacy consistency with original ZOL (Aclasta®) in Chinese postmenopausal women with oste...
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Article
Open AccessIron accumulation deteriorated bone loss in estrogen-deficient rats
Postmenopausal osteoporosis is characterized by an imbalance of bone resorption exceeding bone formation, resulting in a net loss of bone mass. Whether a menopause-related excess of iron contributes to the dev...
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Article
Bone Microthrombus Promotes Bone Loss in Iron Accumulation Rats
In the present study, we investigated the changes of the coagulation state, bone microthrombus, microvascular bed and bone density levels in iron accumulation rats. Meanwhile,the effect of anticoagulation ther...
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Article
Open AccessMiR-708 inhibits MC3T3-E1 cells against H2O2-induced apoptosis through targeting PTEN
The dysregulation of proliferation and apoptosis plays a significant role in the pathogenesis of postmenopausal osteoporosis (PO). MicroRNAs play an important role in regulating apoptosis of MC3T3-E1 cells. Ho...
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Article
Effects of Mouse Hepcidin 1 Treatment on Osteoclast Differentiation and Intracellular Iron Concentration
Hepcidin is a key player in the regulation of mammalian iron homeostasis. Because iron overload may be one of the causes of osteoporosis, hepcidin may have therapeutic potential for osteoporosis patients. Howe...
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Article
Hepcidin1 Knockout Mice Display Defects in Bone Microarchitecture and Changes of Bone Formation Markers
Iron accumulation is a risk factor of osteoporosis; mechanisms leading to iron-related bone loss are not fully determined. We sought to better understand the effect of chronic iron accumulation on bone over t...
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Article
Therapeutic Effect of Deferoxamine on Iron Overload-Induced Inhibition of Osteogenesis in a Zebrafish Model
Osteoporosis results from an imbalance in bone remodeling, in which osteoclastic bone resorption exceeds osteoblastic bone formation. Iron has recently been recognized as an independent risk factor for osteopo...
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Article
Iron Overload Inhibits Osteoblast Biological Activity Through Oxidative Stress
Iron overload has recently been connected with bone mineral density in osteoporosis. However, to date, the effect of iron overload on osteoblasts remains poorly understood. The purpose of this study is to exam...
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Article
A Comparison of the Biological Activities of Human Osteoblast hFOB1.19 Between Iron Excess and Iron Deficiency
Bone metabolism has a close relationship with iron homeostasis. To examine the effects of iron excess and iron deficiency on the biological activities of osteoblast in vitro, human osteoblast cells (hFOB1.19) ...
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Article
Effect of hepcidin on intracellular calcium in human osteoblasts
Hepcidin is known to increase intracellular iron through binding to and degrading ferroportin, which is a transmembrane protein that transports iron from the intracellular to the outside. However, it is not cl...
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Chapter and Conference Paper
Effect of femoral tunnel angle on tunnel enlargement in anterior cruciate ligament reconstructions
The aims of this study were to explore whether the angle of the femoral tunnel had effect on the contact pressure of the graft in the femoral tunnel and to find the best femoral tunnel with the aim of minimizi...
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Article
Ginkgolides protect primary cortical neurons from potassium cyanide-induced hypoxic injury
In this study, we investigated the effects of ginkgolides (Gins A, B, C and J), the main constituent of the non-flavone fraction of EGb 761, on hypoxic injury induced by potassium cyanide (KCN) in primary cort...
