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Open AccessTransmembrane serine protease 6, a novel target for inhibition of neuronal tumor growth
Transmembrane serine protease 6 (Tmprss6) has been correlated with the occurrence and progression of tumors, but any specific molecular mechanism linking the enzyme to oncogenesis has remained elusive thus far...
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Article
Open AccessHepcidin deficiency impairs hippocampal neurogenesis and mediates brain atrophy and memory decline in mice
Hepcidin is the master regulator of iron homeostasis. Hepcidin downregulation has been demonstrated in the brains of Alzheimer’s disease (AD) patients. However, the mechanism underlying the role of hepcidin do...
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Article
Open AccessFerroptosis-related factors in the substantia nigra are associated with Parkinson’s disease
Ferroptosis is an iron-dependent, lipid peroxidation-driven cell death pathway, while Parkinson’s disease (PD) patients exhibit iron deposition and lipid peroxidation in the brain. Thus, the features of ferrop...
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Article
Ferrodifferentiation regulates neurodevelopment via ROS generation
Iron is important for life, and iron deficiency impairs development, but whether the iron level regulates neural differentiation remains elusive. In this study, with iron-regulatory proteins (IRPs) knockout em...
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Article
Open AccessCdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke
Ischemic stroke is associated with high mortality and morbidity rates worldwide. However, the molecular mechanisms underlying the neuronal damage incurred by stroke victims remain unclear. It has previously be...
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Article
Open AccessThe divergent effects of astrocyte ceruloplasmin on learning and memory function in young and old mice
Ceruloplasmin (CP) plays an important role in maintaining iron homeostasis. Cp gene knockout (Cp-/-) mice develop a neurodegenerative disease with aging and show iron accumulation in the brain. However, iron defi...
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Article
A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination
The global emergency caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic can only be solved with effective and widespread preventive and therapeutic strategies, and both are sti...
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Hippocampal Iron Accumulation Impairs Synapses and Memory via Suppressing Furin Expression and Downregulating BDNF Maturation
Brain iron overload is positively correlated with the pathogenesis of Alzheimer’s disease (AD). However, the role of iron in AD pathology is not completely understood. Furin is the first identified mammalian p...
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Open AccessThe emerging role of furin in neurodegenerative and neuropsychiatric diseases
Furin is an important mammalian proprotein convertase that catalyzes the proteolytic maturation of a variety of prohormones and proproteins in the secretory pathway. In the brain, the substrates of furin inclu...
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Article
Open AccessAstrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells
Brain iron dysregulation associated with aging is closely related to motor and cognitive impairments in neurodegenerative diseases. The regulation of iron traffic at the blood-brain barrier (BBB) is crucial to...
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Open AccessMitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis
Ischaemic stroke is becoming the most common cerebral disease in aging populations, but the underlying molecular mechanism of the disease has not yet been fully elucidated. Increasing evidence has indicated th...
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Open AccessHepcidin overexpression in astrocytes alters brain iron metabolism and protects against amyloid-β induced brain damage in mice
Progressive iron accumulation in the brain and iron-induced oxidative stress are considered to be one of the initial causes of Alzheimer’s disease (AD), and modulation of brain iron level shows promise for its...
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Book
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Chapter
Brain Iron Metabolism and Regulation
With the development of research, more and more evidences suggested that mutations in the genes associated with brain iron metabolism induced diseases in the brain. Brain iron metabolism disorders might be one...
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Chapter
Cellular Iron Metabolism and Regulation
Iron is an essential trace element in the human body, but excess iron is toxic as it contributes to oxidative damage. To keep iron concentration within the optimal physiologic range, iron metabolism at the cel...
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Chapter
Brain Iron Metabolism and CNS Diseases
Iron is the most abundant trace element in the human body. It is well known that iron is an important component of hemoglobin involved in the transport of oxygen. As a component of various enzymes, it particip...
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Article
Open AccessDevelopment of real-time recombinase polymerase amplification assay for rapid and sensitive detection of canine parvovirus 2
Canine parvovirus 2, a linear single-stranded DNA virus belonging to the genus Parvovirus within the family Parvoviridae, is a highly contagious pathogen of domestic dogs and several wild canidae species. Early d...
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Article
Open AccessNasal delivery of nanoliposome-encapsulated ferric ammonium citrate can increase the iron content of rat brain
Iron deficiency in children can have significant neurological consequences, and iron supplementation is an effective treatment of choice. However, traditional routes of iron supplementation do not allow effici...
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Article
Open AccessAstrocyte hepcidin is a key factor in LPS-induced neuronal apoptosis
Inflammatory responses involving microglia and astrocytes contribute to the pathogenesis of neurodegenerative diseases (NDs). In addition, inflammation is tightly linked to iron metabolism dysregulation. Howev...
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Article
Mitochondrial ferritin protects the murine myocardium from acute exhaustive exercise injury
Mitochondrial ferritin (FtMt) is a mitochondrially localized protein possessing ferroxidase activity and the ability to store iron. FtMt overexpression in cultured cells protects against oxidative damage by se...
