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13 Result(s)

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  1. Article

    Open Access

    Therapeutic effect of a histone demethylase inhibitor in Parkinson’s disease

    Iron accumulation in the substantia nigra is recognized as a hallmark of Parkinson’s disease (PD). Therefore, reducing accumulated iron and associated oxidative stress is considered a promising therapeutic str...

    Ming-Dao Mu, Zhong-Ming Qian, Sheng-** Yang, Kang-Lin Rong… in Cell Death & Disease (2020)

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  2. Article

    Open Access

    Cystathionine β-synthase (CBS) deficiency suppresses erythropoiesis by disrupting expression of heme biosynthetic enzymes and transporter

    The reduced iron usage induced by the suppression of erythropoiesis is a major cause of the systemic iron overload in CBS knockout (CBS−/−) mice. However, the relevant mechanisms are unknown. Here, we examined ch...

    Peng Zhao, Christopher Qian, Yun-** Chen, Yuan Sheng, Ya Ke… in Cell Death & Disease (2019)

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  3. No Access

    Article

    Different Characteristics of Hepcidin Expression in IL-6+/+ and IL-6−/− Neurons and Astrocytes Treated with Lipopolysaccharides

    A region-specific regulation of inflammation on the expression hepcidin in the brain has been demonstrated, however, it remains unknown whether there is also a cell-specific regulation of inflammation on hepci...

    Juan Ma, Fa-Li Zhang, Gan Zhou, Yu-**n Bao, Yuan Shen… in Neurochemical Research (2018)

  4. No Access

    Article

    Neuroprotective Effects of Lycium barbarum Polysaccharide on Focal Cerebral Ischemic Injury in Mice

    Increasing evidence demonstrates inflammation contributes to neuronal death following cerebral ischemia. Lycium barbarum polysaccharide (LBP) has been reported to prevent scopolamine-induced cognitive and memory ...

    Peng Zhao, Ru Zhou, **ao-Yun Zhu, Gang Liu, Yu-** Zhao… in Neurochemical Research (2017)

  5. No Access

    Article

    Angiotensin II Inhibits Iron Uptake and Release in Cultured Neurons

    Based on the well-confirmed roles of angiotensin II (ANGII) in iron transport of peripheral organs and cells, the causative link of excess brain iron with and the involvement of ANGII in neurodegenerative diso...

    Yong Liu, Suna Huang, Fang Du, Guang Yang, Li Rong Jiang… in Neurochemical Research (2014)

  6. No Access

    Article

    A Synergistic Role of Hyperthermic and Pharmacological Preconditioning to Protect Astrocytes Against Ischemia/Reperfusion Injury

    Recent studies provide solid evidence for the importance to delineate the co-relationship between preconditioning stimuli and therapeutic efficacy of drugs commonly used in clinic. However, very little is know...

    Fang Du, Zhong-ming Qian, Li Zhu, **ao Mei Wu, Wing Ho Yung… in Neurochemical Research (2011)

  7. No Access

    Article

    Nerve Growth Factor Protects the Cortical Neurons from Chemical Hypoxia-induced Injury

    Previous studies showed that nerve growth factor (NGF) exerts protective effects on cultured neurons against various kinds of damage. However, a recent publication reported that exposure of NGF-treated PC12 ce...

    Li Zhu, Fang Du, Lei Yang, **ao Mei Wu, Zhong Ming Qian in Neurochemical Research (2008)

  8. No Access

    Article

    Identification of transcriptionally regulated genes in response to cellular iron availability in rat hippocampus

    The present study was attempted to identify transcriptionally regulated genes of the normal neurocytes responsive to iron availability. Postnatal rat hippocampus cells were primarily cultured either under the ...

    Mei Liu, De-Sheng **ao, Zhong-Ming Qian in Molecular and Cellular Biochemistry (2007)

  9. No Access

    Article

    Molecular analysis of increased iron status in moderately exercised rats

    Although iron plays a critical role in exercise, the regulatory mechanism of iron metabolism remains poorly understood. The aims of the present study were to investigate the effects of different intensity exer...

    Yu Qian Liu, **ang Lin Duan, Yan Zhong Chang… in Molecular and Cellular Biochemistry (2006)

  10. No Access

    Article

    Nitric oxide inhibition decreases bleomycin-detectable iron in spleen, bone marrow cells and heart but not in liver in exercise rats

    The possible role of nitric oxide on the exercise-induced changes in bleomycin-detectable iron (BDI) in the liver, spleen, bone marrow cells and heart was investigated. Female Sprague—Dawley rats were randomly...

    De Sheng **ao, Kwok ** Ho, Zhong Ming Qian in Molecular and Cellular Biochemistry (2004)

  11. No Access

    Article

    Genistein protects primary cortical neurons from iron-induced lipid peroxidation

    Neuroprotective role of isoflavones in particular genistein might be resulted from their antioxidant activities in addition to their estrogenic actions. In the present study, we investigated effect of genistei...

    Kwok ** Ho, Lin Li, Li Zhao, Zhong Ming Qian in Molecular and Cellular Biochemistry (2003)

  12. No Access

    Article

    Hydrogen peroxide enhanced inron-induced injury in isolated heart and ventricular cardiomyocyte in rats

    To explore the cardiac effects of iron with or without hydrogen peroxide, the isolated perfused rat heart and enzymatically isolated ventricular cardiomyocyte were used. It was shown that treatment with cell-p...

    Ying Ying Che Chen, Kwok Pin Ho, Qiang **a… in Molecular and Cellular Biochemistry (2002)

  13. No Access

    Article

    Inhibitory mechanism of lead on transferrin-bound iron uptake by rabbit reticulocytes: A fractal analysis

    Experimental data of transferrin and transferrin-bound iron uptake byrabbit reticulocytes in the presence or absence of extracellular lead isanalyzed by means of a fractal model. A highly significant correlati...

    Zhong Ming Qian, De Sheng **ao, Qin Wang… in Molecular and Cellular Biochemistry (1997)