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Article
Open Accessβ-elemene regulates M1-M2 macrophage balance through the ERK/JNK/P38 MAPK signaling pathway
Macrophages are classified into classically activated M1 macrophages and alternatively activated M2 macrophages, and the two phenotypes of macrophages are present during the development of various chronic dise...
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Article
Open AccessRedesign of a novel d-allulose 3-epimerase from Staphylococcus aureus for thermostability and efficient biocatalytic production of d-allulose
A novel d-allulose 3-epimerase from Staphylococcus aureus (SaDAE) has been screened as a d-allulose 3-epimerase family enzyme based on its high specificity for d-allulose. It usually converts both d-fructose and
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Article
Open AccessEngineering of 3-ketosteroid-∆1-dehydrogenase based site-directed saturation mutagenesis for efficient biotransformation of steroidal substrates
Biosynthesis of steroidal drugs is of great benefit in pharmaceutical manufacturing as the process involves efficient enzymatic catalysis at ambient temperature and atmospheric pressure compared to chemical sy...
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Chapter and Conference Paper
Research Progress of Aldehyde Ketone Reductase for Asymmetric Catalysis of Chiral Compounds
Aldehyde ketone reductase (AKR) belongs to the redox enzyme superfamily. The aldo-keto reductase (AKR) protein superfamily contains over 190 members that fall into 16 families. Its biological catalysis in the ...
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Chapter and Conference Paper
Research Progress of Squalene Synthase on Function and Application
Squalene (SQ) is an unsaturated triterpene which is formed by six linked isoprenes, it is a key intermediate product in the metabolic pathway of cholesterol synthesis. The synthetic process of cholesterol is a...
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Article
Open AccessRational design of cholesterol oxidase for efficient bioresolution of cholestane skeleton substrates
Cholesterol oxidase catalyzes the oxidation and isomerization of the cholestane substrates leading to the addition of a hydroxyl group at the C3 position. Rational engineering of the cholesterol oxidase from Pime...
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Article
Open AccessBiochemical analysis and the preliminary crystallographic characterization of d-tagatose 3-epimerase from Rhodobacter sphaeroides
d-Tagatose 3-epimerase epimerizes d-fructose to yield d-psicose, which is a rare sugar that exists in small quantities in nature and is difficult to synthesize chemically. We aim to ex...
