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Research Progress of Squalene Synthase on Function and Application

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Advances in Applied Biotechnology (ICAB 2016)

Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 444))

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Abstract

Squalene (SQ) is an unsaturated triterpene which is formed by six linked isoprenes, it is a key intermediate product in the metabolic pathway of cholesterol synthesis. The synthetic process of cholesterol is a key step in the biosynthesis of steroids, at the same time this step is a bifurcate point from the isoprenoid central metabolic pathway into the triterpenoid branch biosynthesis. The squalene synthase (SQS) is a key enzyme in isoprenoid synthesis. Two molecules of farnesyl pyrophosphate (FPP) are catalyzed into a 30-carbon linear squalene molecule. This paper systematically reviews the metabolic mechanism, research achievements of SQS, and broad applications in biosynthetic pathways and human health.

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Authors and Affiliations

  1. College of Biotechnology, Tian** University of Science and Technology, Tian**, China

    Dengyue Sun, Qianqian Guo, Zhangliang Zhu, Songtao Li, Jian-Wen Wang, Yu-Fu Zhang, Hui-Min Qin & Fu** Lu

  2. Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tian**, China

    Hui-Min Qin & Fu** Lu

  3. Tian** Key Laboratory of Industrial Microbiology, Tian**, China

    Hui-Min Qin & Fu** Lu

  4. National Engineering Laboratory for Industrial Enzymes, Tian**, 300457, People’s Republic of China

    Hui-Min Qin & Fu** Lu

  5. Food Processing Institute, Heilongjiang Academy of Agricultural Science, 368# Xuefu Road, Nangang District, Harbin, 150086, China

    Lijun Guan

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  1. Dengyue Sun
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Correspondence to Hui-Min Qin or Fu** Lu .

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Editors and Affiliations

  1. College of Biotechnology, Tian** University of Science and Technology, Tian**, China

    Hao Liu

  2. College of Life Sciences, Nankai University, Tian**, China

    Cunjiang Song

  3. Institute of Biology Leiden, Leiden University, Leiden, The Netherlands

    Arthur Ram

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Sun, D. et al. (2018). Research Progress of Squalene Synthase on Function and Application. In: Liu, H., Song, C., Ram, A. (eds) Advances in Applied Biotechnology. ICAB 2016. Lecture Notes in Electrical Engineering, vol 444. Springer, Singapore. https://doi.org/10.1007/978-981-10-4801-2_78

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