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Anti-estrogenic mechanism of unliganded progesterone receptor isoform B in breast cancer cells

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  1. Article

    Open Access

    Elevated NRAS expression during DCIS is a potential driver for progression to basal-like properties and local invasiveness

    Ductal carcinoma in situ (DCIS) is the most common type of in situ premalignant breast cancers. What drives DCIS to invasive breast cancer is unclear. Basal-like invasive breast cancers are aggressive. We have...

    Ze-Yi Zheng, Hanan Elsarraj, Jonathan T. Lei, Yan Hong… in Breast Cancer Research (2022)

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  2. Article

    Open Access

    Induction of N-Ras degradation by flunarizine-mediated autophagy

    Ras GTPases are powerful drivers for tumorigenesis, but directly targeting Ras for treating cancer remains challenging. The growth and transforming activity of the aggressive basal-like breast cancer (BLBC) ar...

    Ze-Yi Zheng, **g Li, Fuhai Li, Yanqiao Zhu, Kemi Cui… in Scientific Reports (2018)

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  3. Article

    Open Access

    Int6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells

    The INT6 gene was first discovered as a site of integration in mouse mammary tumors by the mouse mammary tumor virus; however, INT6’s role in the development of human breast cancer remains largely unknown. By gen...

    **feng Suo, Daniel Medina, Sabrina Herrera, Ze-Yi Zheng, Lei **… in Cell & Bioscience (2015)

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