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Article
Open AccessA neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia
Central leptin action rescues type 1 diabetic (T1D) hyperglycemia; however, the underlying mechanism and the identity of mediating neurons remain elusive. Here, we show that leptin receptor (LepR)-expressing n...
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Article
Open AccessParaventricular hypothalamus mediates diurnal rhythm of metabolism
Defective rhythmic metabolism is associated with high-fat high-caloric diet (HFD) feeding, ageing and obesity; however, the neural basis underlying HFD effects on diurnal metabolism remains elusive. Here we sh...
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Article
Open AccessIdentification of a neurocircuit underlying regulation of feeding by stress-related emotional responses
Feeding is known to be profoundly affected by stress-related emotional states and eating disorders are comorbid with psychiatric symptoms and altered emotional responses. The neural basis underlying feeding re...
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Article
Open AccessA neural basis for antagonistic control of feeding and compulsive behaviors
Abnormal feeding often co-exists with compulsive behaviors, but the underlying neural basis remains unknown. Excessive self-grooming in rodents is associated with compulsivity. Here, we show that optogenetical...
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Article
Open AccessSelective potentiation of 2-APB-induced activation of TRPV1–3 channels by acid
Temperature-sensitive TRP channels are important for responses to pain and inflammation, to both of which tissue acidosis is a major contributing factor. However, except for TRPV1, acid-sensing by other Thermo...
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Article
Dual depolarization responses generated within the same lateral septal neurons by TRPC4-containing channels
In the central nervous system, canonical transient receptor potential (TRPC) channels have been implicated in mediating neuronal excitation induced by stimulating metabotropic receptors, including group 1 meta...
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Article
Open AccessBimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation
Transient receptor potential A1 (TRPA1) is implicated in somatosensory processing and pathological pain sensation. Although not strictly voltage-gated, ionic currents of TRPA1 typically rectify outwardly, indi...
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Article
Quantum Stochastic Linearization of Multi-Linear Interactions
The weak coupling limit for a quantum system, with discrete spectrum, in interaction with a quantum field reservoir is considered. Depending on the nature of the reservoir (i.e. bosonic or fermionic) and the d...
