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Article
Open AccessChronic BDNF simultaneously inhibits and unmasks superficial dorsal horn neuronal activity
Brain-derived neurotrophic factor (BDNF) is critically involved in the pathophysiology of chronic pain. However, the mechanisms of BDNF action on specific neuronal populations in the spinal superficial dorsal ...
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Article
Open AccessParaventricular hypothalamus mediates diurnal rhythm of metabolism
Defective rhythmic metabolism is associated with high-fat high-caloric diet (HFD) feeding, ageing and obesity; however, the neural basis underlying HFD effects on diurnal metabolism remains elusive. Here we sh...
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Article
Open AccessNeuregulin 3 rs10748842 polymorphism contributes to the effect of body mass index on cognitive impairment in patients with schizophrenia
There is evidence that obesity or higher body mass index is correlated with cognitive impairment in schizophrenia. Recent studies have demonstrated that genetic risk factors, such as the NRG3, are correlated with...
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Article
Open AccessIdentification of a neurocircuit underlying regulation of feeding by stress-related emotional responses
Feeding is known to be profoundly affected by stress-related emotional states and eating disorders are comorbid with psychiatric symptoms and altered emotional responses. The neural basis underlying feeding re...
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Article
Open AccessObesity, altered oxidative stress, and clinical correlates in chronic schizophrenia patients
Antipsychotic pharmacotherapy is strongly obesogenic and is associated with increased oxidative stress in patients with schizophrenia. However, whether these changes reflect psychopathology, antipsychotic effi...
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Article
Open AccessA neural basis for antagonistic control of feeding and compulsive behaviors
Abnormal feeding often co-exists with compulsive behaviors, but the underlying neural basis remains unknown. Excessive self-grooming in rodents is associated with compulsivity. Here, we show that optogenetical...
