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Article
Open AccessGanoderma lucidum polysaccharide ameliorates cholesterol gallstone formation by modulating cholesterol and bile acid metabolism in an FXR-dependent manner
Cholesterol gallstone (CG) disease is a worldwide common disease characterized by cholesterol supersaturation in gallbladder bile. Ganoderma lucidum polysaccharide (GLP) has been shown to possess various benefici...
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Article
Open AccessGene polymorphisms of VEGF and KDR are associated with initial fast peritoneal solute transfer rate in peritoneal dialysis
Peritoneal dialysis (PD) is an effective and successful renal replacement therapy. The baseline peritoneal solute transfer rate (PSTR) is related to local membrane inflammation and may be partially genetically...
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Article
Open AccessReflecting on earlier affected areas that shaped COVID-19 mental health efforts
The COVID-19 pandemic is a serious public health threat that many countries in the world are facing. While several measures are being taken to minimize the spread of infection, mental health efforts must addre...
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Article
Open AccessAllosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state
PPM1D encodes a serine/threonine phosphatase that regulates numerous pathways including the DNA damage response and p53. Activating mutations and amplification of PPM1D are found across numerous cancer types. GSK...
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Article
Open AccessBenign and malignant diagnosis of spinal tumors based on deep learning and weighted fusion framework on MRI
The application of deep learning has allowed significant progress in medical imaging. However, few studies have focused on the diagnosis of benign and malignant spinal tumors using medical imaging and age info...
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Article
Open AccessEffect of artificial cycle with or without GnRH-a pretreatment on pregnancy and neonatal outcomes in women with PCOS after frozen embryo transfer: a propensity score matching study
In frozen embryo transfer (FET), there is limited consensus on the best means of endometrial preparation in terms of the reproductive outcomes in women with polycystic ovary syndrome (PCOS). The present study ...
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Article
Open AccessHemoperfusion with HA380 in acute type A aortic dissection patients undergoing aortic arch operation (HPAO): a randomized, controlled, double-blind clinical trial
Cardiopulmonary bypass (CPB) is an important cause of significant systemic inflammatory response syndrome (SIRS) in the surgical treatment of acute type A aortic dissection (ATAAD). In patients with arch vesse...
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Article
Open AccessPublisher Correction: A Fast and Refined Cancer Regions Segmentation Framework in Whole-slide Breast Pathological Images
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessG-protein signaling is required for increasing germline stem cell division frequency in response to mating in Drosophila males
Adult stem cells divide to renew the stem cell pool and replenish specialized cells that are lost due to death or usage. However, little is known about the mechanisms regulating how stem cells adjust to a dema...
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Article
Open AccessA Fast and Refined Cancer Regions Segmentation Framework in Whole-slide Breast Pathological Images
Supervised learning methods are commonly applied in medical image analysis. However, the success of these approaches is highly dependent on the availability of large manually detailed annotated dataset. Thus a...
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Article
Open AccessHaze smoke impacts survival and development of butterflies
The Southeast Asian transboundary haze contains a mixture of gases and particles from forest fires and negatively impacts people’s health and local economies. However, the effect of the haze on organisms other...
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Article
Open AccessEnhanced Defluoridation Using Novel Millisphere Nanocomposite of La-Doped Li-Al Layered Double Hydroxides Supported by Polymeric Anion Exchanger
A novel nanocomposite bead LaLiAl-LDH@201 was fabricated by do** a small amount of La into nanocrystalline Li/Al layered double hydroxides (LDHs) pre-confined inside polystyrene anion exchanger D201 (LiAl-LD...
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Article
Open AccessAssociation of Homocysteine with Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients
Elevated plasma homocysteine (Hcy) is suggested as an independent risk factor for stroke. We aimed to investigate the association of Hcy concentration with intracranial atherosclerosis (ICAS) and extracranial ...
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Article
Open AccessDevelopment and validation of the Chinese version of dry eye related quality of life scale
To develop the Chinese version of quality of life scale for dry eye patients based on the Impact of Dry Eye on Everyday Life (IDEEL) questionnaire and to assess the reliability and validity of the developed sc...
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Article
Open AccessAssociation of Inter-arm Blood Pressure Difference with Asymptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients
Inter-arm blood pressure (BP) difference has been associated with ischemic stroke. Local atherosclerosis of stroke differ among vulnerable individuals, whereas intracranial arterial stenosis (ICAS) is more fre...
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Article
Open AccessIntroducing rapid oral–fluid HIV testing among high risk populations in Shandong, China: feasibility and challenges
This study was conducted to ascertain the feasibility of using rapid oral fluid testing as an alternative HIV testing method in China.
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Article
Open AccessSyndemics of syphilis, HCV infection, and methamphetamine use along the east coast of China
An upsurge in club drug use has been observed in recent years in some cities of China, especially methamphetamine, which is quickly replacing heroin to become the most widespread drug across the nation. This s...
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Article
RETRACTED ARTICLE: Simultaneous expression of antibody light and heavy chains in Pichia pastoris: improving retransformation outcome by linearizing vector at a different site
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Chapter and Conference Paper
Real-Time Plane Segmentation and Obstacle Detection of 3D Point Clouds for Indoor Scenes
Scene analysis is an important issue in computer vision and extracting structural information is one of the fundamental techniques. Taking advantage of depth camera, we propose a novel fast plane segmentation ...
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Article
The relationship between apolipoprotein E ɛ2/ɛ3/ɛ4 polymorphisms and hypertension: a meta-analysis of six studies comprising 1812 cases and 1762 controls
We performed a meta-analysis in an effort to systematically explore the association between apolipoprotein E (ApoE) ɛ2/ɛ3/ɛ4 polymorphisms and hypertension. We searched for case–control studies in English-lang...
