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  1. Article

    Author Correction: Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis

    Wanyan Deng, Yang Bai, Fan Deng, Youdong Pan, Shenglin Mei, Zengzhang Zheng… in Nature (2022)

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    Article

    Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis

    Gasdermins, a family of five pore-forming proteins (GSDMA–GSDME) in humans expressed predominantly in the skin, mucosa and immune sentinel cells, are key executioners of inflammatory cell death (pyroptosis), w...

    Wanyan Deng, Yang Bai, Fan Deng, Youdong Pan, Shenglin Mei, Zengzhang Zheng… in Nature (2022)

  3. Article

    Publisher Correction: Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling

    In this Letter, Supplementary Fig. 1 was missing. This error has been corrected online.

    James B. Eaglesham, Youdong Pan, Thomas S. Kupper, Philip J. Kranzusch in Nature (2019)

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    Article

    Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling

    Cytosolic DNA triggers innate immune responses through the activation of cyclic GMP–AMP synthase (cGAS) and production of the cyclic dinucleotide second messenger 2′,3′-cyclic GMP–AMP (cGAMP)1–4. 2′,3′-cGAMP is a...

    James B. Eaglesham, Youdong Pan, Thomas S. Kupper, Philip J. Kranzusch in Nature (2019)

  5. No Access

    Article

    Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

    FABP4 and FABP5 are important for the maintenance, longevity and function of CD8+ tissue-resident memory T cells, which use oxidative metabolism of exogenous free fatty acids to persist in tissues and to mediate ...

    Youdong Pan, Tian Tian, Chang Ook Park, Serena Y. Lofftus, Shenglin Mei, **ng Liu… in Nature (2017)

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    Article

    Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

    Caspase-mediated cleavage of gasdermin D, previously shown to mediate pyroptosis, acts by inducing oligomerization and pore formation in cell membranes.

    **ng Liu, Zhibin Zhang, Jianbin Ruan, Youdong Pan, Venkat Giri Magupalli, Hao Wu… in Nature (2016)