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Author Correction: Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
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Article
Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
Gasdermins, a family of five pore-forming proteins (GSDMA–GSDME) in humans expressed predominantly in the skin, mucosa and immune sentinel cells, are key executioners of inflammatory cell death (pyroptosis), w...
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Article
Publisher Correction: Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling
In this Letter, Supplementary Fig. 1 was missing. This error has been corrected online.
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Article
Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling
Cytosolic DNA triggers innate immune responses through the activation of cyclic GMP–AMP synthase (cGAS) and production of the cyclic dinucleotide second messenger 2′,3′-cyclic GMP–AMP (cGAMP)1–4. 2′,3′-cGAMP is a...
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Article
Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism
FABP4 and FABP5 are important for the maintenance, longevity and function of CD8+ tissue-resident memory T cells, which use oxidative metabolism of exogenous free fatty acids to persist in tissues and to mediate ...
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Article
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
Caspase-mediated cleavage of gasdermin D, previously shown to mediate pyroptosis, acts by inducing oligomerization and pore formation in cell membranes.