153 Result(s)
-
Article
Cloning and characterization of a mouse liver-specific gene mfrep-1, upregulated in liver regeneration
Human fibrinogen-related protein-1/liver fibrinogen-related protein-1 (HFREP-1/LFIRE-1), a liver-specific protein, is a member of fibrinogen superfamily that exerts various biological activities. However, the ...
-
Article
Embryonic stem cells generated by nuclear transfer of human somatic nuclei into rabbit oocytes
To solve the problem of immune incompatibility, nuclear transplantation has been envisaged as a means to produce cells or tissues for human autologous transplantation. Here we have derived embryonic stem cells...
-
Article
Arabidopsis RAV1 is down-regulated by brassinosteroid and may act as a negative regulator during plant development
RAV1 is a novel DNA-binding protein with two distinct DNA-binding domains unique in higher plants, but its role in plant growth and development remains unknown. Using cDNA array, we found that transcription of RA...
-
Article
Cloning and functional characterization of two cDNAs encoding NADPH-dependent 3-ketoacyl-CoA reductased from develo** cotton fibers
Genes encoding enzymes involved in biosynthesis of very long chain fatty acids were significantly up-regulated during early cotton fiber development. Two cDNAs, GhKCR1 and GhKCR2 encoding putative cotton 3-ketoac...
-
Article
Selection of oocytes for in vitro maturation by brilliant cresyl blue staining: a study using the mouse model
Selecting oocytes that are most likely to develop is crucial for in vitro fertilization and animal cloning. Brilliant cresyl blue (BCB) staining has been used for oocyte selection in large animals, but its wider ...
-
Article
Open AccessComparative study of mesenchymal stem cells from C57BL/10 and mdx mice
Human mesenchymal stem cells (MSCs) have been studied and applied extensively because of their ability to self-renew and differentiate into various cell types. Since most human diseases models are murine, mous...
-
Article
Construction of a chloroplast protein interaction network and functional mining of photosynthetic proteins in Arabidopsis thaliana
Chloroplast is a typical plant cell organelle where photosynthesis takes place. In this study, a total of 1 808 chloroplast core proteins in Arabidopsis thaliana were reliably identified by combining the results ...
-
Article
An R2R3-type transcription factor gene AtMYB59 regulates root growth and cell cycle progression in Arabidopsis
MYB proteins play important roles in eukaryotic organisms. In plants, the R1R2R3-type MYB proteins function in cell cycle control. However, whether the R2R3-type MYB protein is also involved in the cell divisi...
-
Article
Open AccessHypoxia-mimetic agents inhibit proliferation and alter the morphology of human umbilical cord-derived mesenchymal stem cells
The therapeutic efficacy of human mesenchymal stem cells (hMSCs) for the treatment of hypoxic-ischemic diseases is closely related to level of hypoxia in the damaged tissues. To elucidate the potential therape...
-
Article
The E3 ubiquitin ligase MIB1 negatively regulates basal IκBα level and modulates NF-κB activation
-
Article
Phospholipid Scramblase 1 regulates Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells
Toll-like receptor 9 (TLR9) senses microbial DNA in the endosomes of plasmacytoid dendritic cells (pDCs) and triggers MyD88-dependent type I interferon (IFN) responses. To better understand TLR9 biology in pDC...
-
Article
Piglets cloned from induced pluripotent stem cells
-
Article
Open AccessCrystal structures of two phytohormone signal-transducing α/β hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14
-
Article
Open AccessAn ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants
Abscisic acid (ABA) is the most important hormone for plants to resist drought and other abiotic stresses. ABA binds directly to the PYR/PYL family of ABA receptors, resulting in inhibition of type 2C phosphat...
-
Article
Open AccessMammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
The methyltransferase like 3 (METTL3)-containing methyltransferase complex catalyzes the N6-methyladenosine (m6A) formation, a novel epitranscriptomic marker; however, the nature of this complex remains largel...
-
Article
Open AccessRapamycin promoted thrombosis and platelet adhesion to endothelial cells by inducing membrane remodeling
Recently, evidence indicated that the rapamycin-eluting stent which was used worldwide may contribute to an increased risk for thrombosis. On the contrary, other researchers found it was safe. Thus, it is nece...
-
Article
Open AccessPachytene piRNAs instruct massive mRNA elimination during late spermiogenesis
Spermatogenesis in mammals is characterized by two waves of piRNA expression: one corresponds to classic piRNAs responsible for silencing retrotransponsons and the second wave is predominantly derived from non...
-
Article
Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells
The applications of human pluripotent stem cell (hPSC)-derived cells in regenerative medicine has encountered a long-standing challenge: how can we efficiently obtain mature cell types from hPSCs? Attempts to ...
-
Article
Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis
-
Article
Open AccessRecurrent gain-of-function USP8 mutations in Cushing's disease
Cushing's disease, also known as adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas (PAs) that cause excess cortisol production, accounts for up to 85% of corticotrophin-dependent Cushing's syndro...