5 Result(s)
within
Yoav Ben–Shlomo
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessLife course plasma metabolomic signatures of genetic liability to Alzheimer’s disease
Mechanisms through which most known Alzheimer’s disease (AD) loci operate to increase AD risk remain unclear. Although Apolipoprotein E (APOE) is known to regulate lipid homeostasis, the effects of broader AD ...
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Article
Open AccessThe causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization
Alzheimer’s disease (AD) has no proven causal and modifiable risk factors, or effective interventions. We report a phenome-wide association study (PheWAS) of genetic liability for AD in 334,968 participants of...
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Article
Open AccessDysregulation of the hypothalamic pituitary adrenal (HPA) axis and cognitive capability at older ages: individual participant meta-analysis of five cohorts
Evidence on the association between functioning of the hypothalamic pituitary adrenal (HPA) axis and cognitive capability at older ages is mixed. We undertook a systematic review (until October 2016) and indiv...
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Article
Open AccessUsing long term mortality to determine which perioperative risk factors of mortality following hip and knee replacement may be causal
Observational studies have identified surgical factors that are associated with a reduced risk of mortality after joint replacement. It is not clear whether these are causal or reflect patient selection. Data ...
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Article
Open AccessMendelian Randomisation study of the influence of eGFR on coronary heart disease
Impaired kidney function, as measured by reduced estimated glomerular filtration rate (eGFR), has been associated with increased risk of coronary heart disease (CHD) in observational studies, but it is unclear...
