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Article
Open AccessGenetic impacts on DNA methylation help elucidate regulatory genomic processes
Pinpointing genetic impacts on DNA methylation can improve our understanding of pathways that underlie gene regulation and disease risk.
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Living Reference Work Entry In depth
Life Course Epidemiology
Life course epidemiology emerged in the 1990s as a response to the growing rift between differing theoretical models of disease etiology. As such it attempted to synthesize existing approaches within a multile...
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Article
Open AccessChildhood growth and development and DNA methylation age in mid-life
In the first study of its kind, we examine the association between growth and development in early life and DNAm age biomarkers in mid-life.
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Article
The trans-ancestral genomic architecture of glycemic traits
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregate...
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Article
Open AccessVariations of health check attendance in later life: results from a British birth cohort study
Older adults are advised to attend a number of preventive health checks to preserve health and identify risk factors for disease. Previous research has identified a number of health and social factors, labelle...
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Article
Open AccessThe relationship between pubertal timing and markers of vascular and cardiac structure and function in men and women aged 60–64 years
Earlier age at menarche has been associated with higher risk of coronary heart disease, but the mechanisms underlying the association remain unclear. We assessed the relationship of pubertal timing, in both me...
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Article
Open AccessDay-to-day physical activity producing low gravitational impacts is associated with faster visual processing speed at age 69: cross-sectional study
Little is known about how different physical activity (PA) parameters relate to cognitive function in older adults. Using accelerometers calibrated to detect vertical impacts from ground reaction forces we exa...
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Article
Open AccessAre BMI and inflammatory markers independently associated with physical fatigability in old age?
Obesity and chronic low-grade inflammation have both been implicated in the onset of physical fatigue. However, few studies have investigated the independence of these associations in older community-dwelling ...
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Article
Open AccessDysregulation of the hypothalamic pituitary adrenal (HPA) axis and cognitive capability at older ages: individual participant meta-analysis of five cohorts
Evidence on the association between functioning of the hypothalamic pituitary adrenal (HPA) axis and cognitive capability at older ages is mixed. We undertook a systematic review (until October 2016) and indiv...
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Article
Open AccessWork–family life course patterns and work participation in later life
Many developed nations seek to increase older people’s work participation. Work and family are linked to paid work in later life, and to each other. Few studies combined work and family histories using multich...
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Article
Premenopausal cardiovascular disease and age at natural menopause: a pooled analysis of over 170,000 women
Early menopause is associated with an increased risk of subsequent cardiovascular disease (CVD). Few studies have investigated the converse. We examined whether premenopausal CVD events are associated with ear...
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Chapter
A Life Course Approach to Healthy Ageing
The life course epidemiological approach extends the WHO healthy ageing initiative by investigating how physical and mental capacities change across life; how they vary by birth cohort, socioeconomic position,...
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Article
Open AccessUsing a birth cohort to study brain health and preclinical dementia: recruitment and participation rates in Insight 46
Identifying and recruiting people with early pre-symptomatic Alzheimer’s disease to neuroimaging research studies is increasingly important. The extent to which results of these studies can be generalised depe...
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Article
Open AccessGWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of...
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Article
Open AccessAssociations between back pain across adulthood and spine shape in early old age in a British birth cohort
We aimed to examine whether back pain across adulthood was associated with spine shape at age 60–64 years. Data were from 1405 participants in the MRC National Survey of Health and Development, a nationally re...
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Article
Open AccessLifetime cognition and late midlife blood metabolites: findings from a British birth cohort
Maintenance of healthy cognitive ageing is vital for independence and wellbeing in the older general population. We investigated the association between blood metabolites and cognitive function and decline. Pa...
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Article
Open AccessAssociation of longitudinal alcohol consumption trajectories with coronary heart disease: a meta-analysis of six cohort studies using individual participant data
Studies have shown that alcohol intake trajectories differ in their associations with biomarkers of cardiovascular functioning, but it remains unclear if they also differ in their relationship to actual corona...
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Article
Body mass index and age at natural menopause: an international pooled analysis of 11 prospective studies
Current evidence on the association between body mass index (BMI) and age at menopause remains unclear. We investigated the relationship between BMI and age at menopause using data from 11 prospective studies....
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Article
Open AccessHepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption
Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats...
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Article
Open AccessThe prevalence and determinants of polypharmacy at age 69: a British birth cohort study
To describe the development of polypharmacy and its components in a British birth cohort in its seventh decade and to investigate socioeconomic and gender differences independent of disease burden.
