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Article
Open AccessGenome-wide determinants of mortality and motor progression in Parkinson’s disease
There are 90 independent genome-wide significant genetic risk variants for Parkinson’s disease (PD) but currently only five nominated loci for PD progression. The biology of PD progression is likely to be of c...
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Article
Open AccessAssessing the validity of a Parkinson’s care evaluation: the PRIME-NL study
The PRIME-NL study prospectively evaluates a new integrated and personalized care model for people with parkinsonism, including Parkinson’s disease, in a selected region (PRIME) in the Netherlands. We address ...
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Article
Open AccessTwo sample Mendelian Randomisation using an outcome from a multilevel model of disease progression
Identifying factors that are causes of disease progression, especially in neurodegenerative diseases, is of considerable interest. Disease progression can be described as a trajectory of outcome over time—for ...
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Article
Open AccessProdromal multiple sclerosis: considerations and future utility
A multiple sclerosis (MS) prodrome has recently been described and is characterised by increased rates of healthcare utilisation and an excess frequency of fatigue, bladder problems, sensory symptoms and pain,...
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Article
Open AccessLife course plasma metabolomic signatures of genetic liability to Alzheimer’s disease
Mechanisms through which most known Alzheimer’s disease (AD) loci operate to increase AD risk remain unclear. Although Apolipoprotein E (APOE) is known to regulate lipid homeostasis, the effects of broader AD ...
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Article
Open AccessThe elephant in the room: critical reflections on mortality rates among individuals with Parkinson’s disease
In our efforts to create more public awareness about Parkinson’s disease, we often emphasize the tremendous impact of this common disease on an individual’s life. However, in public awareness campaigns, we lar...
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Article
Open AccessGenetic meta-analysis of levodopa induced dyskinesia in Parkinson’s disease
The genetic basis of levodopa-induced-dyskinesia (LiD) is poorly understood, and there have been few well-powered genome-wide studies. We performed a genome-wide survival meta-analyses to study the effect of g...
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Article
Open AccessPrehabilitation for frail patients undergoing total hip or knee replacement: protocol for the Joint PREP feasibility randomised controlled trial
Approximately, 8% of community-based adults aged ≥ 50 years in England are frail. Frailty has been found to be associated with poorer outcomes after joint replacement. Targeting frailty preoperatively via exer...
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Article
Open AccessPatients’ recovery of mobility and return to original residence after hip fracture are associated with multiple modifiable components of hospital service organisation: the REDUCE record-linkage cohort study in England and Wales
Hip fractures are devastating injuries causing disability, dependence, and institutionalisation, yet hospital care is highly variable. This study aimed to determine hospital organisational factors associated w...
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Open AccessCaregiver burden in Parkinson’s disease: a mixed-methods study
Providing informal care for a person with Parkinson’s disease (PD) can be a demanding process affecting several dimensions of a caregiver’s life and potentially causing caregiver burden. Despite the emerging l...
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Article
Open AccessDeterminants of co** styles of people with Parkinson’s Disease
Little is known about how people with Parkinson’s disease (PD) cope with stressful life events. We examined the determinants of specific co** strategies and whether specific choices have any impact on qualit...
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Article
Open AccessProactive and Integrated Management and Empowerment in Parkinson’s Disease protocol for a randomised controlled trial (PRIME-UK) to evaluate a new model of care
People living with Parkinson’s disease experience progressive motor and non-motor symptoms, which negatively impact on health-related quality of life and can lead to an increased risk of hospitalisation. It is...
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Article
Open AccessInvestigating strategies to improve AccesS to Kidney transplantation (the ASK trial): a protocol for a feasibility randomised controlled trial with parallel process evaluation
The UK’s living-donor kidney transplant (LDKT) activity falls behind that of many other countries internationally, with less than 20% of those eligible receiving a LDKT each year. Certain individuals with kidn...
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Living Reference Work Entry In depth
Life Course Epidemiology
Life course epidemiology emerged in the 1990s as a response to the growing rift between differing theoretical models of disease etiology. As such it attempted to synthesize existing approaches within a multile...
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Article
Open AccessTransforming undergraduate education in geriatric medicine: an innovative curriculum at Bristol Medical School
Research and innovation in undergraduate education in geriatric medicine is essential to effectively equip tomorrow’s doctors with the skills and knowledge required to care for older adults with complex health...
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Article
Open AccessUniversal clinical Parkinson’s disease axes identify a major influence of neuroinflammation
There is large individual variation in both clinical presentation and progression between Parkinson’s disease patients. Generation of deeply and longitudinally phenotyped patient cohorts has enormous potential...
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Article
Open AccessStimulation of the Tibial nerve Repetitively to Improve Incontinence in Parkinson’s Electronically (STRIPE trial): a randomised control trial of tibial nerve stimulation for bladder symptoms in Parkinson’s disease using a self-contained wearable device
Bladder symptoms are common in Parkinson’s disease (PD), affecting half of all individuals. These have significant impact on quality of life as well as implications for morbidity, contributing to falls and hos...
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Article
Open AccessThe causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization
Alzheimer’s disease (AD) has no proven causal and modifiable risk factors, or effective interventions. We report a phenome-wide association study (PheWAS) of genetic liability for AD in 334,968 participants of...
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Article
Open AccessThe high-volume haemodiafiltration vs high-flux haemodialysis registry trial (H4RT): a multi-centre, unblinded, randomised, parallel-group, superiority study to compare the effectiveness and cost-effectiveness of high-volume haemodiafiltration and high-flux haemodialysis in people with kidney failure on maintenance dialysis using linkage to routine healthcare databases for outcomes
More than a third of the 65,000 people living with kidney failure in the UK attend a dialysis unit 2–5 times a week to have their blood cleaned for 3–5 h. In haemodialysis (HD), toxins are removed by diffusion...
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Article
Open AccessVerbal fluency as a quick and simple tool to help in deciding when to refer patients with a possible brain tumour
Patients with brain tumours often present with non-specific symptoms. Correctly identifying who to prioritise for urgent brain imaging is challenging. Brain tumours are amongst the commonest cancers diagnosed ...
