54 Result(s)

Article

Assessing the validity of a Parkinson’s care evaluation: the PRIME-NL study

The PRIME-NL study prospectively evaluates a new integrated and personalized care model for people with parkinsonism, including Parkinson’s disease, in a selected region (PRIME) in the Netherlands. We address ...

Liza M. Y. Gelissen, Robin van den Bergh… in European Journal of Epidemiology (2024)

Article

Two sample Mendelian Randomisation using an outcome from a multilevel model of disease progression

Identifying factors that are causes of disease progression, especially in neurodegenerative diseases, is of considerable interest. Disease progression can be described as a trajectory of outcome over time—for ...

Michael Lawton, Yoav Ben-Shlomo, Apostolos Gkatzionis… in European Journal of Epidemiology (2024)

Article

Prodromal multiple sclerosis: considerations and future utility

A multiple sclerosis (MS) prodrome has recently been described and is characterised by increased rates of healthcare utilisation and an excess frequency of fatigue, bladder problems, sensory symptoms and pain,...

Katharine E. Harding, Karim L. Kreft, Yoav Ben-Shlomo… in Journal of Neurology (2024)

Article

Prehabilitation for frail patients undergoing total hip or knee replacement: protocol for the Joint PREP feasibility randomised controlled trial

Approximately, 8% of community-based adults aged ≥ 50 years in England are frail. Frailty has been found to be associated with poorer outcomes after joint replacement. Targeting frailty preoperatively via exer...

Tanzeela Khalid, Yoav Ben-Shlomo, Wendy Bertram… in Pilot and Feasibility Studies (2023)

Article

Patients’ recovery of mobility and return to original residence after hip fracture are associated with multiple modifiable components of hospital service organisation: the REDUCE record-linkage cohort study in England and Wales

Hip fractures are devastating injuries causing disability, dependence, and institutionalisation, yet hospital care is highly variable. This study aimed to determine hospital organisational factors associated w...

Rita Patel, Andrew Judge, Antony Johansen, Elsa M. R. Marques… in BMC Geriatrics (2023)

Article

Caregiver burden in Parkinson’s disease: a mixed-methods study

Providing informal care for a person with Parkinson’s disease (PD) can be a demanding process affecting several dimensions of a caregiver’s life and potentially causing caregiver burden. Despite the emerging l...

Angelika D. Geerlings, Willanka M. Kapelle, Charlotte J. Sederel… in BMC Medicine (2023)

Article

Proactive and Integrated Management and Empowerment in Parkinson’s Disease protocol for a randomised controlled trial (PRIME-UK) to evaluate a new model of care

People living with Parkinson’s disease experience progressive motor and non-motor symptoms, which negatively impact on health-related quality of life and can lead to an increased risk of hospitalisation. It is...

Fiona E. Lithander, Emma Tenison, Jan Y**a, Angelika Halteren, Matthew D. Smith… in Trials (2023)

Article

Investigating strategies to improve AccesS to Kidney transplantation (the ASK trial): a protocol for a feasibility randomised controlled trial with parallel process evaluation

The UK’s living-donor kidney transplant (LDKT) activity falls behind that of many other countries internationally, with less than 20% of those eligible receiving a LDKT each year. Certain individuals with kidn...

Pippa K. Bailey, Fergus J. Caskey, Stephanie MacNeill… in Pilot and Feasibility Studies (2023)

Article

Transforming undergraduate education in geriatric medicine: an innovative curriculum at Bristol Medical School

Research and innovation in undergraduate education in geriatric medicine is essential to effectively equip tomorrow’s doctors with the skills and knowledge required to care for older adults with complex health...

Grace M. E. Pearson, Tomas Welsh, Lucy V. Pocock… in European Geriatric Medicine (2022)

Article

Stimulation of the Tibial nerve Repetitively to Improve Incontinence in Parkinson’s Electronically (STRIPE trial): a randomised control trial of tibial nerve stimulation for bladder symptoms in Parkinson’s disease using a self-contained wearable device

Bladder symptoms are common in Parkinson’s disease (PD), affecting half of all individuals. These have significant impact on quality of life as well as implications for morbidity, contributing to falls and hos...

Matthew D. Smith, Emma Tenison, Marcus J. Drake, Yoav Ben-Shlomo… in Trials (2022)

Article

The high-volume haemodiafiltration vs high-flux haemodialysis registry trial (H4RT): a multi-centre, unblinded, randomised, parallel-group, superiority study to compare the effectiveness and cost-effectiveness of high-volume haemodiafiltration and high-flux haemodialysis in people with kidney failure on maintenance dialysis using linkage to routine healthcare databases for outcomes

More than a third of the 65,000 people living with kidney failure in the UK attend a dialysis unit 2–5 times a week to have their blood cleaned for 3–5 h. In haemodialysis (HD), toxins are removed by diffusion...

Fergus J. Caskey, Sunita Procter, Stephanie J. MacNeill, Julia Wade, Jodi Taylor… in Trials (2022)

Article

Verbal fluency as a quick and simple tool to help in deciding when to refer patients with a possible brain tumour

Patients with brain tumours often present with non-specific symptoms. Correctly identifying who to prioritise for urgent brain imaging is challenging. Brain tumours are amongst the commonest cancers diagnosed ...

Karolis Zienius, Mio Ozawa, Willie Hamilton, Will Hollingworth… in BMC Neurology (2022)

Article

Interpretation of vaccine associated neurological adverse events: a methodological and historical review

As a result of significant recent scientific investment, the range of vaccines available for COVID-19 prevention continues to expand and uptake is increasing globally. Although initial trial safety data have b...

Marija Cauchi, Harriet Ball, Yoav Ben-Shlomo, Neil Robertson in Journal of Neurology (2022)

Article

Correction to: Alendronate use and bone mineral density gains in women with moderate-severe (stages 3B–5) chronic kidney disease: an open cohort multivariable and propensity score analysis from Funen, Denmark

M. Sanni Ali, Martin Ernst, Danielle E. Robinson, Fergus Caskey… in Archives of Osteoporosis (2021)

Article

Rationale and design to evaluate the PRIME Parkinson care model: a prospective observational evaluation of proactive, integrated and patient-centred Parkinson care in The Netherlands (PRIME-NL)

Culminating evidence shows that current care does not optimally meet the needs of persons with parkinsonism, their carers and healthcare professionals. Recently, a new model of care was developed to address th...

Jan H. L. Y**a, Angelika D. Van Halteren, Emily J. Henderson… in BMC Neurology (2021)

Article

Associations of GP practice characteristics with the rate of ambulatory care sensitive conditions in people living with dementia in England: an ecological analysis of routine data

Hospital admissions for Ambulatory Care Sensitive Conditions (ACSCs) are potentially avoidable. Dementia is one of the leading chronic conditions in terms of variability in ACSC admissions by general practice,...

Emily Eyles, Maria Theresa Redaniel, Sarah Purdy… in BMC Health Services Research (2021)

Article

The Dementias Platform UK (DPUK) Data Portal

The Dementias Platform UK Data Portal is a data repository facilitating access to data for 3 370 929 individuals in 42 cohorts. The Data Portal is an end-to-end data management solution providing a secure, ful...

Sarah Bauermeister, Christopher Orton, Simon Thompson… in European Journal of Epidemiology (2020)

Article

Alendronate use and bone mineral density gains in women with moderate-severe (stages 3B–5) chronic kidney disease: an open cohort multivariable and propensity score analysis from Funen, Denmark

Bisphosphonates are contraindicated in moderate-to-severe chronic kidney disease patients. However, they are used to prevent fragility fractures in patients with impaired kidney function, despite a lack of evi...

M. Sanni Ali, Martin Ernst, Danielle E. Robinson, Fergus Caskey… in Archives of Osteoporosis (2020)

Article

Estimating the risk of acute kidney injury associated with use of diuretics and renin angiotensin aldosterone system inhibitors: A population based cohort study using the clinical practice research datalink

The risk of acute kidney injury (AKI) attributable to renin angiotensin aldosterone (RAAS) inhibitors and diuretics remains unclear.

Jemima Scott, Tim Jones, Maria Theresa Redaniel, Margaret T. May… in BMC Nephrology (2019)