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within Yinon Ben-Neriah Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter

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  1. No Access

    Article

    The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic

    Somatic mutations in p53, which inactivate the tumour-suppressor function of p53 and often confer oncogenic gain-of-function properties, are very common in cancer1,2. Here we studied the effects of hotspot gain-o...

    Eliran Kadosh, Irit Snir-Alkalay, Avanthika Venkatachalam, Shahaf May… in Nature (2020)

  2. No Access

    Article

    CKIα ablation highlights a critical role for p53 in invasiveness control

    In a mouse model of intestinal cancer, Yinon Ben-Neriah and colleagues show that in the absence of CK1-α, the loss of p53 dramatically enhances tumour progression and metastasis. The tumour repressor p53 norma...

    Ela Elyada, Ariel Pribluda, Robert E. Goldstein, Yael Morgenstern, Guy Brachya… in Nature (2011)

  3. No Access

    Article

    NF-κB functions as a tumour promoter in inflammation-associated cancer

    The causes of sporadic human cancer are seldom recognized, but it is estimated that carcinogen exposure and chronic inflammation are two important underlying conditions for tumour development, the latter accou...

    Eli Pikarsky, Rinnat M. Porat, Ilan Stein, Rinat Abramovitch, Sharon Amit… in Nature (2004)

  4. No Access

    Article

    Identification of the receptor component of the IκBα–ubiquitin ligase

    NF-κB, a ubiquitous, inducible transcription factor involved in immune, inflammatory, stress and developmental processes, is retained in a latent form in the cytoplasm of non-stimulated cells by inhibitory mol...

    Avraham Yaron, Ada Hatzubai, Matti Davis, Iris Lavon, Sharon Amit… in Nature (1998)

  5. No Access

    Article

    Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

    INDUCIBLE gene expression in eukaryotes is mainly controlled by the activity of transcriptional activator proteins, such as NF-κB (refs 1–3), a factor activated upon treatment of cells with phorbolesters, lipo...

    Thomas Henkel, Thomas Machleidt, Irit Alkalay, Martin Krönke, Yinon Ben-Neriah… in Nature (1993)

  6. No Access

    Article

    Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain

    Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation1. The protein-tyrosine kinases described to date are either transmembrane prote...

    Yinon Ben-Neriah, Asne R. Bauskin in Nature (1988)

  7. No Access

    Article

    Isolation and expression of a complementary DNA that confers multidrug resistance

    The emergence and outgrowth of a population of tumour cells resistant to multiple drugs is a major problem in the chemotherapeutic treatment of cancer. We have used highly drug-resistant cell lines developed in v...

    Philippe Gros, Yinon Ben Neriah, James M. Croop, David E. Housman in Nature (1986)

  8. No Access

    Article

    T-cell hybridoma bearing heavy chain variable region determinants producing (T,G)-A--L-specific helper factor

    Thymus-derived lymphocytes (T cells) exert their regulatory effect (help or suppression) on the antibody production by B cells either by direct cell to cell interaction or by soluble mediators or factors1,2. The ...

    Zelig Eshhar, Ron N. Apte, Ilana Löwy, Yinon Ben-Neriah, David Givol, Edna Mozes in Nature (1980)

  9. No Access

    Article

    Alloactivated Lyt 1 +2− T lymphoblasts bind syngeneic Ia antigens

    A large proportion of T blasts activated in the mixed lymphocyte reaction (MLR) is capable of binding plasma membrane (PM) vesicles prepared from the stimulator strain1,2. The binding of vesicles is specific, and...

    Bruce E. Elliott, Zoltan A. Nagy, Yinon Ben-Neriah, David Givol in Nature (1980)

  10. No Access

    Article

    Allotype-linked genetic control of a polymorphic VH framework determinant on mouse T-helper cell receptors

    The immune system confronts antigens through the variable domains of antigen receptors on lymphocytes. The biochemistry of these antigen receptors is fundamental to the understanding of the immune system. Whil...

    Yinon Ben Neriah, David Givol, P. Lonai, Markus M. Simon, Klaus Eichmann in Nature (1980)